Peptide-based Drug Discovery: Challenges and New Therapeutics
With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies.
What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines.
The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.
Peptide-based Drug Discovery: Challenges and New Therapeutics, The Royal Society of Chemistry, 2017.
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Table of contents
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CHAPTER 1: Renaissance in Peptide Drug Discovery: The Third Wavep1-34ByTomi K. SawyerTomi K. SawyerSearch for other works by this author on:
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CHAPTER 2: Identification and Validation of Peptide Therapeutic Targets and Indicationsp35-75ByAndrew A. YoungAndrew A. YoungIntarcia Therapeutics Inc.6 Davis Drive, Research Triangle ParkNC 27709United States[email protected]Search for other works by this author on:
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CHAPTER 3: Peptide Biomarkers and Assay Developmentp76-115ByN. K. Rana;N. K. RanaSeton Hall University, Department of Chemistry and Biochemistry400 South Orange Ave.South OrangeNew Jersey07079USA[email protected]Search for other works by this author on:M. Phillips;M. PhillipsSeton Hall University, Department of Chemistry and Biochemistry400 South Orange Ave.South OrangeNew Jersey07079USA[email protected]Search for other works by this author on:E. Carrión;E. CarriónSeton Hall University, Department of Chemistry and Biochemistry400 South Orange Ave.South OrangeNew Jersey07079USA[email protected]Search for other works by this author on:G. Luisi;G. LuisiSeton Hall University, Department of Chemistry and Biochemistry400 South Orange Ave.South OrangeNew Jersey07079USA[email protected]Search for other works by this author on:D. SabatinoD. SabatinoSeton Hall University, Department of Chemistry and Biochemistry400 South Orange Ave.South OrangeNew Jersey07079USA[email protected]Search for other works by this author on:
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CHAPTER 4: Peptide Library Technologies: Mixture-Based Library Generation and Screeningp116-140ByColette T. DooleyColette T. DooleyTorrey Pines Institute for Molecular Studies11350 S.W. Village ParkwayPort St. LucieFL 34987USA[email protected]Search for other works by this author on:
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CHAPTER 5: Macrocyclic Peptides for Intracellular Drug Targetsp141-171BySerge Zaretsky;Serge ZaretskyUniversity of Toronto, Lash Miller Chemical Labs80 St. George StreetTorontoONM5S 3H6Canada[email protected]Search for other works by this author on:Andrei K. YudinAndrei K. YudinUniversity of Toronto, Lash Miller Chemical Labs80 St. George StreetTorontoONM5S 3H6Canada[email protected]Search for other works by this author on:
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CHAPTER 6: Structural Design for Bioactive Peptidesp172-191ByG. S. Jedhe;G. S. JedheOrganic Chemistry Division, CSIR-National Chemistry LaboratoryDr Homi Bhabha RoadPune 411008India[email protected]Search for other works by this author on:G. J. SanjayanG. J. SanjayanOrganic Chemistry Division, CSIR-National Chemistry LaboratoryDr Homi Bhabha RoadPune 411008India[email protected]Search for other works by this author on:
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CHAPTER 7: Peptide Lead Optimization—Strategies and Tacticsp192-222ByJane V. AldrichJane V. AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of FloridaP.O. Box 100485GainesvilleFL 32610USA[email protected]Search for other works by this author on:
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CHAPTER 8: ADME Properties of Peptide Therapeutics in Drug Discovery and Developmentp223-251ByS. G. RollerS. G. RollerIntarcia Therapeutics, Drug Metabolism and Pharmacokinetics6 Davis Drive, Research Triangle ParkNC27709USA[email protected]Search for other works by this author on:
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CHAPTER 9: Optimizing Peptides for Metabolic Diseasesp252-277ByRam DharanipragadaRam DharanipragadaSearch for other works by this author on:
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CHAPTER 10: Peptide Therapeutics: Oncologyp278-325ByRuiwu Liu;Ruiwu LiuDepartment of Biochemistry and Molecular Medicine, University of California Davis2700 Stockton BoulevardSacramentoCalifornia 95817USAUniversity of California Davis Comprehensive Cancer Center2279 45th StreetSacramentoCalifornia 95817USASearch for other works by this author on:Xiaocen Li;Xiaocen LiDepartment of Biochemistry and Molecular Medicine, University of California Davis2700 Stockton BoulevardSacramentoCalifornia 95817USAUniversity of California Davis Comprehensive Cancer Center2279 45th StreetSacramentoCalifornia 95817USASearch for other works by this author on:Tsung-Chieh Shih;Tsung-Chieh ShihDepartment of Biochemistry and Molecular Medicine, University of California Davis2700 Stockton BoulevardSacramentoCalifornia 95817USAUniversity of California Davis Comprehensive Cancer Center2279 45th StreetSacramentoCalifornia 95817USASearch for other works by this author on:Joyce S. Lee;Joyce S. LeeUniversity of California Davis Comprehensive Cancer Center2279 45th StreetSacramentoCalifornia 95817USADepartment of Pharmacy, University of California Davis2315 Stockton BlvdSacramentoCalifornia 95817USADivision of Hematology & Oncology, Department of Internal Medicine, University of California Davis4501 X StreetSacramentoCalifornia 95817USA[email protected]Search for other works by this author on:Kit S. LamKit S. LamDepartment of Biochemistry and Molecular Medicine, University of California Davis2700 Stockton BoulevardSacramentoCalifornia 95817USAUniversity of California Davis Comprehensive Cancer Center2279 45th StreetSacramentoCalifornia 95817USADivision of Hematology & Oncology, Department of Internal Medicine, University of California Davis4501 X StreetSacramentoCalifornia 95817USA[email protected]Search for other works by this author on:
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CHAPTER 11: Development of Peptide-Based Diagnostic and Therapeutic Agents in Oncologyp326-363ByKamala KesavanKamala KesavanSearch for other works by this author on:
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CHAPTER 12: Designing an Effective Peptide Vaccinep364-390ByA. PessiA. PessiSearch for other works by this author on:
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CHAPTER 13: Peptide Therapeutics: Neuropeptidesp391-410ByVictor J. Hruby;Victor J. HrubyUniversity of Arizona, Department of Chemistry and Biochemistry1306 E University, P.O. Box 210041TucsonArizona 85721USA[email protected]Search for other works by this author on:Yeon Sun Lee;Yeon Sun LeeUniversity of Arizona, Department of Chemistry and Biochemistry1306 E University, P.O. Box 210041TucsonArizona 85721USA[email protected]Search for other works by this author on:Minying Cai;Minying CaiUniversity of Arizona, Department of Chemistry and Biochemistry1306 E University, P.O. Box 210041TucsonArizona 85721USA[email protected]Search for other works by this author on:Keith Olson;Keith OlsonUniversity of Arizona, Department of Chemistry and Biochemistry1306 E University, P.O. Box 210041TucsonArizona 85721USA[email protected]Search for other works by this author on:Michael RemesicMichael RemesicUniversity of Arizona, Department of Chemistry and Biochemistry1306 E University, P.O. Box 210041TucsonArizona 85721USA[email protected]Search for other works by this author on:
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CHAPTER 14: From Spider Toxins to Therapeutics—Developing Selective Nav1.7 Peptide Inhibitors for Painp411-437ByChengzao SunChengzao SunSearch for other works by this author on:
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CHAPTER 15: Structure and Function of Stress-Responsive Peptides in Insectsp438-451ByLynn G. Schrag;Lynn G. SchragDepartment of Biochemistry and Molecular Biophysics, Kansas State UniversityManhattanKS 66506USA[email protected]Search for other works by this author on:Alvaro I. Herrera;Alvaro I. HerreraDepartment of Biochemistry and Molecular Biophysics, Kansas State UniversityManhattanKS 66506USA[email protected]Search for other works by this author on:Xiaolong Cao;Xiaolong CaoDepartment of Entomology and Plant Pathology, Oklahoma State UniversityStillwaterOK 74078USA[email protected]Search for other works by this author on:Om Prakash;Om PrakashDepartment of Biochemistry and Molecular Biophysics, Kansas State UniversityManhattanKS 66506USA[email protected]Search for other works by this author on:Haobo JiangHaobo JiangDepartment of Entomology and Plant Pathology, Oklahoma State UniversityStillwaterOK 74078USA[email protected]Search for other works by this author on:
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CHAPTER 16: Technologies for Oral Delivery of Peptidesp452-496
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CHAPTER 17: Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target-Directed Screensp497-517ByPaul M. Watt;Paul M. WattTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Tatjana Heinrich;Tatjana HeinrichTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Robert E. Dewhurst;Robert E. DewhurstTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Shane R. Stone;Shane R. StoneTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Richard W. Francis;Richard W. FrancisTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Renae K. Barr;Renae K. BarrTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Heique M. Bogdawa;Heique M. BogdawaTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:Nadia MilechNadia MilechTelethon Kids Institute, The University of Western Australia100 Roberts RoadSubiacoWestern Australia 6008AustraliaSearch for other works by this author on:
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CHAPTER 18: Solid-Phase Peptide Synthesis, the State of the Art: Challenges and Opportunitiesp518-550ByYahya E. Jad;Yahya E. JadCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-NatalDurban 4001South AfricaSearch for other works by this author on:Ayman El-Faham;Ayman El-FahamDepartment of Chemistry, College of Science, King Saud UniversityP.O. Box 2455Riyadh 11451Saudi ArabiaDepartment of Chemistry, Faculty of Science, Alexandria UniversityP.O. Box 426Ibrahimia, Alexandria 21321EgyptSearch for other works by this author on:Beatriz G. de la Torre;Beatriz G. de la TorreCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-NatalDurban 4001South AfricaSearch for other works by this author on:Fernando AlbericioFernando AlbericioCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-NatalDurban 4001South AfricaDepartment of Chemistry, College of Science, King Saud UniversityP.O. Box 2455Riyadh 11451Saudi ArabiaCIBER-BBN, Networking Centre on Bioengineering, Biomaterials and NanomedicineBarcelona Science Park08028-BarcelonaSpainDepartment of Organic Chemistry, University of Barcelona08028-BarcelonaSpainSchool of Chemistry and Physics, University of KwaZulu-NatalDurban 4001South Africa[email protected][email protected]Search for other works by this author on:
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