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Drug Discovery
Peptide-based Drug Discovery: Challenges and New Therapeutics
Edited by
Ved Srivastava
Ved Srivastava
Global Peptide Science Institute (GPSi), USA
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Hardback ISBN:
978-1-78262-732-6
PDF ISBN:
978-1-78801-153-2
EPUB ISBN:
978-1-78801-171-6
Special Collection:
2017 ebook collection
Series:
Drug Discovery Series
No. of Pages:
588
Published online:
22 Jun 2017
Published in print:
26 Jun 2017
Book Chapter
CHAPTER 18: Solid-Phase Peptide Synthesis, the State of the Art: Challenges and Opportunities
By
Yahya E. Jad
;
Yahya E. Jad
Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal
Durban 4001
South Africa
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Ayman El-Faham
;
Ayman El-Faham
Department of Chemistry, College of Science, King Saud University
P.O. Box 2455
Riyadh 11451
Saudi Arabia
Department of Chemistry, Faculty of Science, Alexandria University
P.O. Box 426
Ibrahimia, Alexandria 21321
Egypt
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Beatriz G. de la Torre
;
Beatriz G. de la Torre
Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal
Durban 4001
South Africa
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Fernando Albericio
Fernando Albericio
Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal
Durban 4001
South Africa
Department of Chemistry, College of Science, King Saud University
P.O. Box 2455
Riyadh 11451
Saudi Arabia
CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine
Barcelona Science Park
08028-Barcelona
Spain
Department of Organic Chemistry, University of Barcelona
08028-Barcelona
Spain
School of Chemistry and Physics, University of KwaZulu-Natal
Durban 4001
South Africa
[email protected][email protected]
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Published:22 Jun 2017
-
Special Collection: 2017 ebook collectionSeries: Drug Discovery Series
Page range:
518 - 550
Citation
Y. E. Jad, A. El-Faham, B. G. de la Torre, and F. Albericio, in Peptide-based Drug Discovery: Challenges and New Therapeutics, ed. V. Srivastava, The Royal Society of Chemistry, 2017, pp. 518-550.
Download citation file:
Solid-phase peptide synthesis (SPPS) methodology is one of the principles responsible for the large number of peptides in the market and, more importantly, in the clinical phases pipeline. This chapter examines the state of the art of SPPS and defines the scope and limitations for identifying the new directions required to fulfill the needs of society—needs that ultimately drive all scientific processes.
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