Stevia rebaudiana requires little introduction in this chapter. Steviol glycosides are considered to be the main plant secondary metabolites of interests, adding value to the plant material due to their sweetness.¹  Both in the European Union and the US, purified steviol glycosides have been approved as food additives and found application in many calorie-reduced foods. However, many consumers purchase stevia leaf material on markets or via the internet or grow stevia in their own garden using the leaf material directly. Such leaf material is pending approval as a novel food both in the EU and the US. The use of the leaf material will inevitably lead to human consumption of all further secondary metabolites produced by this plant. Many of these metabolites add additional health benefits to the leaf material adding extra value to the product. Additionally, approval of the leaf material will maintain a livelihood for farmers and agricultural cooperatives cultivating the undemanding stevia crop on “poor soils”.