Contrast Agents for MRI: Experimental Methods
As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents.
The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.
Contrast Agents for MRI: Experimental Methods, The Royal Society of Chemistry, 2017.
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Chapter 1: General Synthetic and Physical Methodsp1-120ByQuyen N. Do;Quyen N. DoDepartment of Radiology, University of Texas Southwestern Medical CenterDallasTX 75390USASearch for other works by this author on:James S. Ratnakar;James S. RatnakarAdvanced Imaging Research Center, University of Texas SouthwesternDallasTX 75390USA[email protected]Search for other works by this author on:Zoltán Kovács;Zoltán KovácsAdvanced Imaging Research Center, University of Texas SouthwesternDallasTX 75390USA[email protected]Search for other works by this author on:Gyula Tircsó;Gyula TircsóDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of DebrecenH-4010 DebrecenHungary[email protected]Search for other works by this author on:Ferenc Krisztián Kálmán;Ferenc Krisztián KálmánDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of DebrecenH-4010 DebrecenHungary[email protected]Search for other works by this author on:Zsolt Baranyai;Zsolt BaranyaiDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of DebrecenH-4010 DebrecenHungary[email protected]Search for other works by this author on:Ernő Brücher;Ernő BrücherDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of DebrecenH-4010 DebrecenHungary[email protected]Search for other works by this author on:Imre TóthImre TóthDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of DebrecenH-4010 DebrecenHungary[email protected]Search for other works by this author on:
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Chapter 2: Gadolinium-based Contrast Agentsp121-242ByLothar Helm;Lothar HelmEcole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, BCH1015 LausanneSwitzerland[email protected]Search for other works by this author on:Janet R. Morrow;Janet R. MorrowUniversity at Buffalo, State University of New York, Department of ChemistryAmherstNY 14260USA[email protected]Search for other works by this author on:Christopher J. Bond;Christopher J. BondUniversity at Buffalo, State University of New York, Department of ChemistryAmherstNY 14260USA[email protected]Search for other works by this author on:Fabio Carniato;Fabio CarniatoDipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”15121 AlessandriaItaly[email protected]Search for other works by this author on:Mauro Botta;Mauro BottaDipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”15121 AlessandriaItaly[email protected]Search for other works by this author on:Mihály Braun;Mihály BraunIsotope Climatology and Environmental Research Centre (ICER), Institute for Nuclear Research, Hungarian Academy of SciencesH-4026 DebrecenHungarySearch for other works by this author on:Zsolt Baranyai;Zsolt BaranyaiDepartment of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of DebrecenH-4010 DebrecenHungarySearch for other works by this author on:Rosa Pujales-Paradela;Rosa Pujales-ParadelaCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña15008 A CoruñaSpain[email protected]Search for other works by this author on:Martín Regueiro-Figueroa;Martín Regueiro-FigueroaCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña15008 A CoruñaSpain[email protected]Search for other works by this author on:David Esteban-Gómez;David Esteban-GómezCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña15008 A CoruñaSpain[email protected]Search for other works by this author on:Carlos Platas-Iglesias;Carlos Platas-IglesiasCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña15008 A CoruñaSpain[email protected]Search for other works by this author on:Timothy J. SchollTimothy J. SchollMedical Biophysics and Robarts Research Institute, Western UniversityLondonN6A 3K7 ONCanada[email protected]Search for other works by this author on:
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Chapter 3: Chemical Exchange Saturation Transfer (CEST) Contrast Agentsp243-317ByGiuseppe Ferrauto;Giuseppe FerrautoMolecular Imaging Center, Department of Molecular Biotechnologies and Health Sciences, University of Torino10126 TorinoItaly[email protected]Search for other works by this author on:Silvio Aime;Silvio AimeMolecular Imaging Center, Department of Molecular Biotechnologies and Health Sciences, University of Torino10126 TorinoItaly[email protected]Search for other works by this author on:Michael T. McMahon;Michael T. McMahonThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of MedicineMD 21205USA[email protected]F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger InstituteBaltimoreMD 21205USASearch for other works by this author on:Janet R. Morrow;Janet R. MorrowUniversity at Buffalo, State University of New York, Department of ChemistryAmherstNY 14260USA[email protected]Search for other works by this author on:Eric M. Snyder;Eric M. SnyderUniversity at Buffalo, State University of New York, Department of ChemistryAmherstNY 14260USA[email protected]Search for other works by this author on:Alex Li;Alex LiRobarts Research Institute, University of Western OntarioLondonOntario N6A 3K7Canada[email protected]Search for other works by this author on:Robert BarthaRobert BarthaRobarts Research Institute, University of Western OntarioLondonOntario N6A 3K7Canada[email protected]Departments of Medical Biophysics, Medical Imaging, and Psychiatry, University of Western OntarioLondonOntario N6A 3K7CanadaSearch for other works by this author on:
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Chapter 4: Iron-oxide Nanoparticle-based Contrast Agentsp318-447ByDimitri Stanicki;Dimitri StanickiLaboratory of NMR and Molecular Imaging, Department of General, Organic and Biomedical Chemistry, University of Mons19 7000MonsBelgium[email protected]Search for other works by this author on:Luce Vander Elst;Luce Vander ElstLaboratory of NMR and Molecular Imaging, Department of General, Organic and Biomedical Chemistry, University of Mons19 7000MonsBelgium[email protected]CMMI – Center for Microscopy and Molecular Imaging8 6041GosseliesBelgiumSearch for other works by this author on:Robert N. Muller;Robert N. MullerLaboratory of NMR and Molecular Imaging, Department of General, Organic and Biomedical Chemistry, University of Mons19 7000MonsBelgium[email protected]CMMI – Center for Microscopy and Molecular Imaging8 6041GosseliesBelgiumSearch for other works by this author on:Sophie Laurent;Sophie LaurentLaboratory of NMR and Molecular Imaging, Department of General, Organic and Biomedical Chemistry, University of Mons19 7000MonsBelgium[email protected]CMMI – Center for Microscopy and Molecular Imaging8 6041GosseliesBelgiumSearch for other works by this author on:Jean-Marc Greneche;Jean-Marc GrenecheIMMM UMR CNRS 6283 Université du Maine72085Le MansFranceSearch for other works by this author on:Vlad Socoliuc;Vlad SocoliucRomanian Academy-Timisoara Branch, Center for Fundamental and Advanced Technical Research, Lab. Magnetic FluidsRO-300223TimisoaraRomania[email protected]Search for other works by this author on:Victor Kuncser;Victor KuncserNational Institute of Materials Physics077125Bucharest-MagureleRomaniaSearch for other works by this author on:Rodica Turcu;Rodica TurcuNational Institute R&D for Isotopic and Molecular TechnologiesRO-400293Cluj-NapocaRomaniaSearch for other works by this author on:Ladislau Vékás;Ladislau VékásRomanian Academy-Timisoara Branch, Center for Fundamental and Advanced Technical Research, Lab. Magnetic FluidsRO-300223TimisoaraRomania[email protected]Search for other works by this author on:Paula Foster;Paula FosterRobarts Research Institute, University of Western OntarioLondonONN6A 3K7CanadaDepartment of Medical Biophysics, University of Western OntarioLondonONN6A 3K7CanadaSearch for other works by this author on:Robert BarthaRobert BarthaRobarts Research Institute, University of Western OntarioLondonONN6A 3K7CanadaDepartment of Medical Biophysics, University of Western OntarioLondonONN6A 3K7CanadaDepartments of Medical Imaging and Psychiatry, University of Western OntarioLondonONN6A 3K7Canada[email protected]Search for other works by this author on:
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Chapter 5: Transition Metal-based T1 Contrast Agentsp448-478ByRosa Pujales-Paradela;Rosa Pujales-ParadelaCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química, Universidade da Coruña15008CoruñaSpain[email protected]Search for other works by this author on:Martín Regueiro-Figueroa;Martín Regueiro-FigueroaCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química, Universidade da Coruña15008CoruñaSpain[email protected]Search for other works by this author on:David Esteban-Gómez;David Esteban-GómezCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química, Universidade da Coruña15008CoruñaSpain[email protected]Search for other works by this author on:Carlos Platas-IglesiasCarlos Platas-IglesiasCentro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química, Universidade da Coruña15008CoruñaSpain[email protected]Search for other works by this author on:
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Chapter 6: Fluorine-based Contrast Agentsp479-498ByPaula Foster;Paula FosterRobarts Research Institute, University of Western OntarioLondonOntarioN6A 3K7CanadaDepartment of Medical Biophysics, University of Western OntarioLondonOntarioN6A 3K7CanadaSearch for other works by this author on:Alex Li;Alex LiRobarts Research Institute, University of Western OntarioLondonOntarioN6A 3K7CanadaSearch for other works by this author on:Robert BarthaRobert BarthaRobarts Research Institute, University of Western OntarioLondonOntarioN6A 3K7CanadaDepartment of Medical Biophysics, University of Western OntarioLondonOntarioN6A 3K7CanadaDepartments of Medical Imaging and Psychiatry, University of Western OntarioLondonOntarioN6A 3K7Canada[email protected]Search for other works by this author on:
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Chapter 7: Standard Biological and in vivo Methodsp499-584ByTang Tang;Tang TangChemistry Graduate Group, University of CaliforniaDavisCA95616USASearch for other works by this author on:Angelique Y. Louie;Angelique Y. LouieChemistry Graduate Group, University of CaliforniaDavisCA95616USASearch for other works by this author on:Eric M. Gale;Eric M. GaleA. A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestonMA02129USA[email protected][email protected][email protected]Search for other works by this author on:Peter Caravan;Peter CaravanA. A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestonMA02129USA[email protected][email protected][email protected]Search for other works by this author on:Christian T. Farrar;Christian T. FarrarA. A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestonMA02129USA[email protected][email protected][email protected]Search for other works by this author on:Boris KeilBoris KeilA. A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestonMA02129USA[email protected][email protected][email protected]Search for other works by this author on:
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