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New Developments in NMR
Contrast Agents for MRI: Experimental MethodsCheck Access
Edited by
Valérie C Pierre;
Valérie C Pierre
University of Minnesota, USA
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Matthew J Allen
Matthew J Allen
Wayne State University, USA
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Hardback ISBN:
978-1-78262-447-9
PDF ISBN:
978-1-78801-014-6
EPUB ISBN:
978-1-78801-254-6
Special Collection:
2017 ebook collection
Series:
New Developments in NMR
No. of Pages:
598
Published online:
09 Nov 2017
Published in print:
17 Nov 2017
Book Chapter
Chapter 2: Gadolinium-based Contrast Agents Check Access
By
Lothar Helm
;
Lothar Helm
Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, BCH
1015 Lausanne
Switzerland
[email protected]
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Janet R. Morrow
;
Janet R. Morrow
University at Buffalo, State University of New York, Department of Chemistry
Amherst
NY 14260
USA
[email protected]
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Christopher J. Bond
;
Christopher J. Bond
University at Buffalo, State University of New York, Department of Chemistry
Amherst
NY 14260
USA
[email protected]
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Fabio Carniato
;
Fabio Carniato
Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”
15121 Alessandria
Italy
[email protected]
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Mauro Botta
;
Mauro Botta
Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”
15121 Alessandria
Italy
[email protected]
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Mihály Braun
;
Mihály Braun
Isotope Climatology and Environmental Research Centre (ICER), Institute for Nuclear Research, Hungarian Academy of Sciences
H-4026 Debrecen
Hungary
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Zsolt Baranyai
;
Zsolt Baranyai
Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen
H-4010 Debrecen
Hungary
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Rosa Pujales-Paradela
;
Rosa Pujales-Paradela
Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña
15008 A Coruña
Spain
[email protected]
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Martín Regueiro-Figueroa
;
Martín Regueiro-Figueroa
Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña
15008 A Coruña
Spain
[email protected]
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David Esteban-Gómez
;
David Esteban-Gómez
Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña
15008 A Coruña
Spain
[email protected]
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Carlos Platas-Iglesias
;
Carlos Platas-Iglesias
Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña
15008 A Coruña
Spain
[email protected]
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Timothy J. Scholl
Timothy J. Scholl
Medical Biophysics and Robarts Research Institute, Western University
London
N6A 3K7 ON
Canada
[email protected]
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Published:09 Nov 2017
-
Special Collection: 2017 ebook collectionSeries: New Developments in NMR
Page range:
121 - 242
Citation
L. Helm, J. R. Morrow, C. J. Bond, F. Carniato, M. Botta, M. Braun, ... T. J. Scholl, in Contrast Agents for MRI: Experimental Methods, ed. V. C. Pierre and M. J. Allen, The Royal Society of Chemistry, 2017, ch. 2, pp. 121-242.
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In this chapter, the development of efficient GdIII-based agents for MRI is detailed. This chapter is divided into ten sections covering the general theory of the relaxivity of GdIII-based contrast agents; the measurement of longitudinal (T1) and transverse (T2) relaxation times; the theory, acquisition, and interpretation of NMRD profiles; the determination of water-coordination numbers (q), rotational-correlation times (τR), water-residence times (τM), and concentrations of solutions of GdIII complexes; as well as relaxometric titrations, computational methods, and the acquisition of phantom images.
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