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The ultimate goal of stem cell therapy is to replace surgery with injection of stem cells into a trauma site with localized cell proliferation and differentiation to heal a particular tissue or organ. Thermogelling composite systems have been investigated as biodegradable, injectable 3D scaffolds for stem cell proliferation and differentiation. These thermogels have been successfully used as cultivating media; however, certain additives have proved necessary for the stem cells to be able to differentiate in vitro (e.g. graphene oxide for adipogenesis and calcium phosphate crystals for osteogenesis). This chapter summarizes the great strides that have been made and what remains to be done in this exciting field.

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