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Poly(ethylene glycol-b-[dl-lactic acid-co-glycolic acid]-b-ethylene glycol (PEG-PLGA-PEG)-based hydrogels demonstrate reversible sol-to-gel transitions at temperatures near body temperature, making it a promising material for many applications. This review summarizes synthetic methods, physical and biochemical properties, applications in drug delivery, gene delivery and postoperation adhesion prevention. The issues for future direction are highlighted.

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