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Drug Discovery
Acute Brain Impairment: Scientific Discoveries and Translational Research
Edited by
Philip V Peplow;
Philip V Peplow
University of Otago, New Zealand
Search for other works by this author on:
Svetlana A Dambinova;
Svetlana A Dambinova
Kennesaw State University
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Thomas A Gennarelli;
Thomas A Gennarelli
George Washington University, USA
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Bridget Martinez
Bridget Martinez
University of California, Merced, USA
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Hardback ISBN:
978-1-78262-950-4
PDF ISBN:
978-1-78801-253-9
EPUB ISBN:
978-1-78801-337-6
Special Collection:
2017 ebook collection
Series:
Drug Discovery
No. of Pages:
348
Published online:
17 Nov 2017
Published in print:
22 Nov 2017
About this book
A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of scientific advancements in these areas.
Chapters provide the latest knowledge in neuroscience, biotechnology, and personalized medicine applicable to acute brain injuries. Development of neuroprotective drugs is treated in detail. Chemical biomarkers for detection, imaging and preventative strategies are covered to provide medicinal chemists with a broad view of translational aspects of the field.
This book will be useful to postgraduate students and researchers in medicinal chemistry and pharmacology as well as specialists in the acute brain injury field.
Acute Brain Impairment: Scientific Discoveries and Translational Research, The Royal Society of Chemistry, 2017.
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Digital access
$209.00
Print format
Acute Brain Impairment
$209.00
Table of contents
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Chapter 1: Transient Ischemic Attack, Traumatic Brain Injury, and Ischemic Stroke: Risk Factors and Treatmentsp1-14ByJacqueline J. T. LiawJacqueline J. T. LiawSearch for other works by this author on:
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Chapter 2: Inflammatory Changes in Cerebral Ischemic Injury: Cellular and Molecular Involvementp15-33ByHiroaki OoboshiHiroaki OoboshiDepartment of Internal Medicine, Fukuoka Dental College Medical and Dental HospitalFukuoka 814-0193Japan[email protected]Search for other works by this author on:
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Chapter 3: Biomarkers of Acute Brain Injury and Surrogate Endpoints in Traumatic Brain Injury and Stroke Translational Studiesp34-50ByLinda PapaLinda PapaDepartment of Emergency Medicine, Orlando Regional Medical CenterOrlandoFloridaUSADepartment of Neurology and Neurosurgery, McGill University, 86 W. Underwood (S-200)OrlandoFlorida 32806USA[email protected]Search for other works by this author on:
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Chapter 4: Difficulties of Translating Outcomes from Animal Studies to Clinical Trialsp51-63ByPhilip V. Peplow;Philip V. PeplowDepartment of Anatomy, University of OtagoDunedinNew ZealandSearch for other works by this author on:Bridget MartinezBridget MartinezSearch for other works by this author on:
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Chapter 5: Neuroprotective Therapies for Ischemic Strokep64-81ByYolanda Cruz;Yolanda CruzUniversidad Anáhuac México Campus NorteAv. Universidad Anáhuac No. 46, Lomas Anáhuac, HuixquilucanEstado de México 52764MéxicoSearch for other works by this author on:Karla Cantu-Saldaña;Karla Cantu-SaldañaUniversidad Anáhuac México Campus NorteAv. Universidad Anáhuac No. 46, Lomas Anáhuac, HuixquilucanEstado de México 52764MéxicoSearch for other works by this author on:Antonio IbarraAntonio IbarraUniversidad Anáhuac México Campus NorteAv. Universidad Anáhuac No. 46, Lomas Anáhuac, HuixquilucanEstado de México 52764MéxicoCentro de Investigación del Proyecto CAMINAAv. Universidad Anáhuac No. 46, Lomas Anáhuac, HuixquilucanEstado de México 52764México[email protected]Search for other works by this author on:
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Chapter 6: The Molecular Neuroprotective Strategies in Cerebral Ischemia: An Insight into Emerging Treatments for Oxidative Stressp82-104BySreekala S. Nampoothiri;Sreekala S. NampoothiriSchool of Biotechnology, National Institute of Technology CalicutCalicut 673601KeralaIndia[email protected]Search for other works by this author on:Saurabh A. Jain;Saurabh A. JainSheffield Institute for Translational Neuroscience, University of Sheffield385a Glossop RoadSheffield S10 2HQUKSearch for other works by this author on:David Burrows;David BurrowsSheffield Institute for Translational Neuroscience, University of Sheffield385a Glossop RoadSheffield S10 2HQUKSearch for other works by this author on:Ok-Nam Bae;Ok-Nam BaeCollege of Pharmacy, Hanyang UniversityAnsan 15588Republic of KoreaSearch for other works by this author on:Arshad Majid;Arshad MajidSheffield Institute for Translational Neuroscience, University of Sheffield385a Glossop RoadSheffield S10 2HQUKSearch for other works by this author on:G. K. RajanikantG. K. RajanikantSchool of Biotechnology, National Institute of Technology CalicutCalicut 673601KeralaIndia[email protected]Search for other works by this author on:
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Chapter 7: Identification of MicroRNAs as Targets for Treatment of Ischemic Strokep105-127ByCreed M. Stary;Creed M. StaryStanford University School of Medicine, Dept. Anesthesiology, Perioperative & Pain Medicine300 Pasteur DriveStanfordCA94305-5117USA[email protected]Search for other works by this author on:Josh D. Bell;Josh D. BellStanford University School of Medicine, Dept. Anesthesiology, Perioperative & Pain Medicine300 Pasteur DriveStanfordCA94305-5117USA[email protected]University of Toronto School of Medicine, Dept. AnesthesiologyRoom 1200, 12th Floor, 123 Edward StreetTorontoONM5G 1E2CanadaSearch for other works by this author on:Jang Eun Cho;Jang Eun ChoStanford University School of Medicine, Dept. Anesthesiology, Perioperative & Pain Medicine300 Pasteur DriveStanfordCA94305-5117USA[email protected]Anam Hospital, Korea University College of Medicine, Department of Anesthesiology and Pain Medicine73 Inchon-roSeongbuk-gu, SeoulSouth KoreaSearch for other works by this author on:Rona G. GiffardRona G. GiffardStanford University School of Medicine, Dept. Anesthesiology, Perioperative & Pain Medicine300 Pasteur DriveStanfordCA94305-5117USA[email protected]Search for other works by this author on:
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Chapter 8: Combined Drug–Diagnostic Test Co-development for Predicting and Preventing Brain Impairmentsp128-140ByShean PhelpsShean PhelpsGeorgia Institute of TechnologyAtlantaGeorgiaUSASearch for other works by this author on:
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Chapter 9: Advances in Diagnostics and Treatment of Neurotoxicity after Sports-related Injuriesp141-161ByThomas A. Gennarelli;Thomas A. GennarelliMedical College of WisconsinWest ChesterPAUSAGeorge Washington UniversityWashingtonDCUSASearch for other works by this author on:Joseph D. WeissmanJoseph D. WeissmanSearch for other works by this author on:
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Chapter 10: Functional Predictors for Prognosis and Recovery after Mild Traumatic Brain Injuryp162-175ByA. M. Sufrinko;A. M. SufrinkoUniversity of Pittsburgh Medical Center Sports Concussion Program, Department of Orthopedic Surgery3200 S. Water St.PittsburghPA 15203USA[email protected]Search for other works by this author on:N. Sandel;N. SandelUniversity of Pittsburgh Medical Center Sports Concussion Program, Department of Orthopedic Surgery3200 S. Water St.PittsburghPA 15203USA[email protected]Search for other works by this author on:A. PuskarA. PuskarUniversity of Pittsburgh Medical Center Sports Concussion Program, Department of Orthopedic Surgery3200 S. Water St.PittsburghPA 15203USA[email protected]Search for other works by this author on:
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Chapter 11: Predictors for Prognosis and Recovery from Unconsciousness Due to Brain Traumap176-197ByA. A. Potapov;A. A. PotapovN.N. Burdenko National Scientific and Practical Centre for Neurosurgery4th Tverskaya-Yamskaya 16125047MoscowRussia[email protected]Search for other works by this author on:E. V. Alexandrova;E. V. AlexandrovaN.N. Burdenko National Scientific and Practical Centre for Neurosurgery4th Tverskaya-Yamskaya 16125047MoscowRussia[email protected]Search for other works by this author on:S. A. Dambinova;S. A. DambinovaDeKalb Medical CentreAtlantaGAUSASearch for other works by this author on:N. E. Zakharova;N. E. ZakharovaN.N. Burdenko National Scientific and Practical Centre for Neurosurgery4th Tverskaya-Yamskaya 16125047MoscowRussia[email protected]Search for other works by this author on:G. V. DanilovG. V. DanilovN.N. Burdenko National Scientific and Practical Centre for Neurosurgery4th Tverskaya-Yamskaya 16125047MoscowRussia[email protected]Search for other works by this author on:
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Chapter 12: Neurotoxicity in Spinal Cord Impairmentsp198-213BySvetlana A. Dambinova;Svetlana A. DambinovaDeKalb MedicalDecaturGAUSASearch for other works by this author on:Alexander A. SkorometsAlexander A. SkorometsSearch for other works by this author on:
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Chapter 13: Advanced Approaches in Stem Cell Therapy for Stroke and Traumatic Brain Injuryp214-241ByA. GorodinskyA. GorodinskySearch for other works by this author on:
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Chapter 14: Testing and Mechanisms of Neuroprotective Agents for Cerebral Ischemic Injury in Clinical Trials, 2010–2016p242-262ByJ. F. FraserJ. F. FraserSearch for other works by this author on:
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Chapter 15: Difficulties in Clinical Trials to Treat Traumatic Brain Injury and Strokep263-275ByAlfonso Lagares;Alfonso LagaresDepartment of NeurosurgeryHospital 12 de Octubre de Madrid, Instituto de Investigación imas12, Universidad Complutense de MadridMadridSpain[email protected]Search for other works by this author on:María de ToledoMaría de ToledoDepartment of Neurology, Hospital Universitario La PrincesaMadridSpainSearch for other works by this author on:
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Chapter 16: Challenges in Using Biomarkers in Central Nervous System Applicationsp276-288ByJohn D. MullinsJohn D. MullinsPiedmont HospitalAtlantaGAUSASearch for other works by this author on:
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Chapter 17: Resolving Difficult Case Scenarios by Incorporating Stroke Biomarkers in Clinical Decision-makingp289-314ByGeelyn J. L. Ng;Geelyn J. L. NgDepartment of Medicine, Yong Loo Lin School of Medicine, National University of SingaporeSingapore[email protected]Division of Neurology, Department of Medicine, National University Health SystemNUHS Tower Block Level 10, 1E Kent Ridge RoadSingapore 119228SingaporeSearch for other works by this author on:Ei Z. The;Ei Z. TheDivision of Neurology, Department of Medicine, National University Health SystemNUHS Tower Block Level 10, 1E Kent Ridge RoadSingapore 119228SingaporeSearch for other works by this author on:Mei Yen Ng;Mei Yen NgDepartment of Medicine, Yong Loo Lin School of Medicine, National University of SingaporeSingapore[email protected]Division of Neurology, Department of Medicine, National University Health SystemNUHS Tower Block Level 10, 1E Kent Ridge RoadSingapore 119228SingaporeSearch for other works by this author on:Amy M. L. Quek;Amy M. L. QuekDepartment of Medicine, Yong Loo Lin School of Medicine, National University of SingaporeSingapore[email protected]Division of Neurology, Department of Medicine, National University Health SystemNUHS Tower Block Level 10, 1E Kent Ridge RoadSingapore 119228SingaporeSearch for other works by this author on:Raymond C. S. SeetRaymond C. S. SeetDepartment of Medicine, Yong Loo Lin School of Medicine, National University of SingaporeSingapore[email protected]Division of Neurology, Department of Medicine, National University Health SystemNUHS Tower Block Level 10, 1E Kent Ridge RoadSingapore 119228SingaporeSearch for other works by this author on:
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Chapter 18: Development of Novel Test Platforms for the Assessment of Brain Injuryp315-326ByRichard Baldwin;Richard BaldwinNanocomposixSan DiegoCAUSASearch for other works by this author on:Steven J. OldenburgSteven J. OldenburgNanocomposixSan DiegoCAUSASearch for other works by this author on:
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Chapter 19: Advancements and Challenges in Hyperacute Stroke Translational Researchp327-340ByPhilip V. Peplow;Philip V. PeplowDepartment of Anatomy, University of OtagoDunedinNew ZealandSearch for other works by this author on:Thomas A. GennarelliThomas A. GennarelliMedical College of WisconsinWest ChesterPAUSAGeorge Washington UniversityWashingtonDCUSASearch for other works by this author on:
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