Chapter 12: Neurotoxicity in Spinal Cord Impairments

Spinal cord (SC) ischemia is a rare but devastating disorder caused by trauma and a wide range of diseases directly or indirectly affecting the SC vascular system. Specific biomarkers for SC ischemia combined with coherent guidelines could aid the early diagnosis of disease, target treatment development, and reduce mortality. The present chapter is devoted to the role of neurotoxicity cascade in the hemodynamics of SC impairment. Tendencies in early diagnosis and treatment of acute and chronic conditions are highlighted.