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Cerebrovascular disorders and traumatic brain injury-centric personalized therapeutics (i.e., “Rx” or “targeted drugs” and/or therapies) and companion diagnostics are discussed in regard to improving clinical outcomes by proffering patient treatments that are tailored toward their distinctive biological characteristics. The application of personalized medicine in the face of the challenges surrounding predicting and preventing the development of impairment in persons with pre-existing conditions and/or increased risk factors are addressed.

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