Therapies for Retinal Degeneration: Targeting Common Processes
Sight loss and blindness is a very prevalent cause of disability. Retinal diseases leading to visual loss affect many people worldwide and the search for adequate drugs remains a challenge and an important area of interest in the drug discovery field. This book addresses approaches to the treatment of retinal diseases, targeting common processes and components. Despite their causative origins, which comprise genetic dystrophies, age-related degenerations, as well as pathologies associated with other diseases, a neurodegenerative component appears, sooner or later, in the course of the disease. As is the case for most neurodegenerative diseases, the available treatments are far from satisfactory. The aim of this book is to highlight research and drug development efforts in targeting such common processes as a potential path to provide treatments to the millions of affected people.
Therapies for Retinal Degeneration: Targeting Common Processes, The Royal Society of Chemistry, 2018.
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Table of contents
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CHAPTER 1: The Cellular Course of Retinal Degenerative Conditionsp1-30ByVictoria Maneu;Victoria ManeuOptics, Pharmacology and Anatomy, University of AlicanteAlicanteSpainSearch for other works by this author on:Pedro LaxPedro LaxSearch for other works by this author on:
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CHAPTER 2: Immune Response of the Retinap31-47ByMei CHEN;Mei CHENCentre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University BelfastUniversity RoadBelfastBT7 1NNUK[email protected]Search for other works by this author on:Heping XuHeping XuCentre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University BelfastUniversity RoadBelfastBT7 1NNUK[email protected]Search for other works by this author on:
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CHAPTER 3: Modulation of Calcium Overload and Calpain Activityp48-60ByFrançois Paquet-Durand;François Paquet-DurandInstitute for Ophthalmic Research, University of TübingenGermanySearch for other works by this author on:Per Ekström;Per EkströmOphthalmology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversitySwedenSearch for other works by this author on:Valeria MarigoValeria MarigoDepartment of Life Sciences, University of Modena and Reggio Emiliavia G. Campi 28741125 ModenaItaly[email protected]Search for other works by this author on:
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CHAPTER 4: CNS Targets for the Treatment of Retinal Dystrophies: A Win–Win Strategyp61-75ByEnrique J. de la Rosa;Enrique J. de la Rosa3D Lab, Dept. of Molecular Biomedicine, Centro de Investigaciones Biológicas CSICC/ Ramiro de Maeztu 928040MadridSpain[email protected]Search for other works by this author on:Catalina Hernández-SánchezCatalina Hernández-Sánchez3D Lab, Dept. of Molecular Biomedicine, Centro de Investigaciones Biológicas CSICC/ Ramiro de Maeztu 928040MadridSpain[email protected]Search for other works by this author on:
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CHAPTER 5: Modulation of p75NTR/Pro-NGF as a Therapeutic Approach for Degenerative Retinopathiesp76-87ByH. Uri Saragovi;H. Uri SaragoviDepartments of Pharmacology and Therapeutics, Ophthalmology, Integrated Program for Neuroscience, McGill UniversityMontrealQCCanadaSearch for other works by this author on:Pablo F. BarcelonaPablo F. BarcelonaCentro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas, UNCCórdobaArgentinaSearch for other works by this author on:
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CHAPTER 6: Modulation of cGMP-signalling to Prevent Retinal Degenerationp88-98ByValeria Marigo;Valeria MarigoDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio EmiliaItalySearch for other works by this author on:Per Ekström;Per EkströmOphthalmology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund UniversitySwedenSearch for other works by this author on:Frank Schwede;Frank SchwedeBiolog Life Science InstituteBremenGermanySearch for other works by this author on:Andreas Rentsch;Andreas RentschBiolog Life Science InstituteBremenGermanySearch for other works by this author on:François Paquet-DurandFrançois Paquet-DurandSearch for other works by this author on:
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CHAPTER 7: PEDF Peptides in Retinal Degenerationsp99-112ByAlberto M. Hernández-Pinto;Alberto M. Hernández-Pinto3D Lab, Dept Molecular Biomedicine, Centro de Investigaciones Biológicas CSICC/ Ramiro de Maeztu 928040 MadridSpainSearch for other works by this author on:S. Patricia BecerraS. Patricia BecerraSearch for other works by this author on:
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CHAPTER 8: Beyond Anti-inflammation: Steroid-induced Neuroprotection in the Retinap113-143ByAlice C. Wyse-Jackson;Alice C. Wyse-JacksonCell Death and Development Laboratory, Department of Biochemistry, Biosciences Institute, University College CorkCorkIreland[email protected]Search for other works by this author on:Gillian Groeger;Gillian GroegerCell Death and Development Laboratory, Department of Biochemistry, Biosciences Institute, University College CorkCorkIreland[email protected]Search for other works by this author on:Thomas G. CotterThomas G. CotterCell Death and Development Laboratory, Department of Biochemistry, Biosciences Institute, University College CorkCorkIreland[email protected]Search for other works by this author on:
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CHAPTER 9: Alternative Experimental Models of Ciliary Trafficking and Dysfunction in the Retinap144-163ByStephen P. Carter;Stephen P. CarterUCD School of Biomolecular and Biomedical Science, University College DublinBelfieldDublin 4Ireland[email protected]UCD Conway Institute, University College DublinBelfieldDublin 4IrelandSearch for other works by this author on:Janina Leyk;Janina LeykDepartment of Neuroscience, University of OldenburgOldenburgGermanySearch for other works by this author on:Oliver E. Blacque;Oliver E. BlacqueUCD School of Biomolecular and Biomedical Science, University College DublinBelfieldDublin 4Ireland[email protected]UCD Conway Institute, University College DublinBelfieldDublin 4IrelandSearch for other works by this author on:Breandán KennedyBreandán KennedyUCD School of Biomolecular and Biomedical Science, University College DublinBelfieldDublin 4Ireland[email protected]UCD Conway Institute, University College DublinBelfieldDublin 4IrelandSearch for other works by this author on:
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CHAPTER 10: Drug Delivery Systems for the Treatment of Diseases Affecting the Retina and Optic Nervep164-178ByI. Bravo-Osuna;I. Bravo-OsunaComplutense University, Pharmaceutical Innovation in Ophthalmology Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of PharmacyPlaza Ramón y Cajal s/nMadrid28040Spain[email protected]Ocular Pathology National Net (OFTARED) of the Institute of Health Carlos III, Spain, Health Research Institute of the San Carlos Clinical Hospital (IdISSC)MadridSpainSearch for other works by this author on:V. Andrés-Guerrero;V. Andrés-GuerreroComplutense University, Pharmaceutical Innovation in Ophthalmology Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of PharmacyPlaza Ramón y Cajal s/nMadrid28040Spain[email protected]Ocular Pathology National Net (OFTARED) of the Institute of Health Carlos III, Spain, Health Research Institute of the San Carlos Clinical Hospital (IdISSC)MadridSpainSearch for other works by this author on:Irene T. Molina-Martínez;Irene T. Molina-MartínezComplutense University, Pharmaceutical Innovation in Ophthalmology Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of PharmacyPlaza Ramón y Cajal s/nMadrid28040Spain[email protected]Ocular Pathology National Net (OFTARED) of the Institute of Health Carlos III, Spain, Health Research Institute of the San Carlos Clinical Hospital (IdISSC)MadridSpainSearch for other works by this author on:R. Herrero-VanrellR. Herrero-VanrellComplutense University, Pharmaceutical Innovation in Ophthalmology Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of PharmacyPlaza Ramón y Cajal s/nMadrid28040Spain[email protected]Ocular Pathology National Net (OFTARED) of the Institute of Health Carlos III, Spain, Health Research Institute of the San Carlos Clinical Hospital (IdISSC)MadridSpainSearch for other works by this author on:
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CHAPTER 11: Gene Therapies for Retinal Degenerationsp179-195ByL. Petit;L. PetitUniversity of Massachusetts Medical School, Department of Ophthalmology & Horae Gene Therapy Center368 Plantation StreetWorcester01605-2324USA[email protected]Search for other works by this author on:V. KalatzisV. KalatzisInstitute for Neurosciences of Montpellier, Inserm U105180 rue Augustin Fliche34091MontpellierFranceSearch for other works by this author on:
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CHAPTER 12: Stem Cell Therapies for Retinal Repair and Regenerationp196-215ByKaren Eastlake;Karen EastlakeUCL Institute of Ophthalmology, NIHR Biomedical Research Centre at Moorfields Eye Hospital11-43 Bath StreetLondon EC1V 9ELUK[email protected]Search for other works by this author on:Weixin Wang;Weixin WangUCL Institute of Ophthalmology, NIHR Biomedical Research Centre at Moorfields Eye Hospital11-43 Bath StreetLondon EC1V 9ELUK[email protected]Search for other works by this author on:William D. B. Lamb;William D. B. LambUCL Institute of Ophthalmology, NIHR Biomedical Research Centre at Moorfields Eye Hospital11-43 Bath StreetLondon EC1V 9ELUK[email protected]Search for other works by this author on:G. Astrid LimbG. Astrid LimbUCL Institute of Ophthalmology, NIHR Biomedical Research Centre at Moorfields Eye Hospital11-43 Bath StreetLondon EC1V 9ELUK[email protected]Search for other works by this author on:
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CHAPTER 13: The Application of Lipid Nanoparticles for Retinal Degenerative Diseasesp216-229ByRaju V. S. Rajala;Raju V. S. RajalaDepartment of Ophthalmology, University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USADepartment of Physiology, University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USADepartment of Cell Biology, University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USASearch for other works by this author on:Ammaji Rajala;Ammaji RajalaDepartment of Ophthalmology, University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USASearch for other works by this author on:Yuhong WangYuhong WangDepartment of Ophthalmology, University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USASearch for other works by this author on:
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CHAPTER 14: Biologicals in Retinal Therapyp230-255ByEmma Connolly;Emma ConnollyDept. Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2 and The National Children's Research Centre, Our Lady's Children's Hospital CrumlinDublin 12Ireland[email protected]Search for other works by this author on:Sarah L. DoyleSarah L. DoyleDept. Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2 and The National Children's Research Centre, Our Lady's Children's Hospital CrumlinDublin 12Ireland[email protected]Search for other works by this author on:
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