CHAPTER 3: Modulation of Calcium Overload and Calpain Activity
Published:13 Sep 2018
F. Paquet-Durand, P. Ekström, and V. Marigo, in Therapies for Retinal Degeneration: Targeting Common Processes, ed. E. J. de la Rosa and T. G. Cotter, The Royal Society of Chemistry, 2018, pp. 48-60.
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Fluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.