Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology
Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.
Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, The Royal Society of Chemistry, 2018.
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Table of contents
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Synthetic Tools for the Elucidation of Biological Mechanismsp1-7ByNicholas Westwood;Nicholas WestwoodBiomolecular Sciences Research Complex, University of St Andrews, North HaughSt Andrews KY16 9STUK[email protected]Search for other works by this author on:Adam NelsonAdam NelsonSchool of Chemistry, University of LeedsLeeds LS2 9JTUKAstbury Centre for Structural Molecular Biology, University of LeedsLeeds LS2 9JTUKSearch for other works by this author on:
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Chapter 2: The Application of Diversity-oriented Synthesis in Chemical Biologyp8-44ByDavid R. SpringDavid R. SpringSearch for other works by this author on:
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Chapter 3: Biology-oriented Synthesisp45-73ByGeorge Karageorgis;George KarageorgisMax-Planck-Institute for Molecular Physiology, Department of Chemical BiologyOtto-Hahn str. 1144227 DortmundGermany[email protected]Search for other works by this author on:Herbert WaldmannHerbert WaldmannMax-Planck-Institute for Molecular Physiology, Department of Chemical BiologyOtto-Hahn str. 1144227 DortmundGermany[email protected]Search for other works by this author on:
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Chapter 4: Lead- and Fragment-oriented Synthesisp74-113ByPeter O'BrienPeter O'BrienSearch for other works by this author on:
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Chapter 5: Principles and Applications of Fragment-based Drug Discovery for Chemical Probesp114-137ByMoses Moustakim;Moses MoustakimStructural Genomics Consortium (SGC) & Target Discovery Institute (TDI), University of OxfordNDM Research Building, Roosevelt Drive, OX3 7DQ and OX3 7FZOxfordUK[email protected]Department of Chemistry, Chemistry Research Laboratory, University of OxfordMansfield RoadOxford OX1 3TAUKSearch for other works by this author on:Paul E. BrennanPaul E. BrennanStructural Genomics Consortium (SGC) & Target Discovery Institute (TDI), University of OxfordNDM Research Building, Roosevelt Drive, OX3 7DQ and OX3 7FZOxfordUK[email protected]ARUK Oxford Drug Discovery Institute, University of OxfordNDM Research Building, Roosevelt DriveOX3 7FZ OxfordUKSearch for other works by this author on:
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Chapter 6: Function-driven Discovery of Bioactive Small Moleculesp138-152BySamuel Liver;Samuel LiverAstbury Centre for Structural Molecular Biology, University of LeedsLeeds LS2 9JTUKSearch for other works by this author on:Jacob Masters;Jacob MastersAstbury Centre for Structural Molecular Biology, University of LeedsLeeds LS2 9JTUKSearch for other works by this author on:Adam NelsonAdam NelsonAstbury Centre for Structural Molecular Biology, University of LeedsLeeds LS2 9JTUKSearch for other works by this author on:
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Chapter 7: DNA-encoded Library Technology (ELT)p153-183ByGang Yao;Gang YaoGlaxoSmithKline, Platform of Technology and Science200 Cambridge Park DriveCambridgeMA 02140USA[email protected]Search for other works by this author on:Xiaojie Lu;Xiaojie LuGlaxoSmithKline, Platform of Technology and Science200 Cambridge Park DriveCambridgeMA 02140USA[email protected]Search for other works by this author on:Chris Phelps;Chris PhelpsGlaxoSmithKline, Platform of Technology and Science200 Cambridge Park DriveCambridgeMA 02140USA[email protected]Search for other works by this author on:Ghotas EvindarGhotas EvindarGlaxoSmithKline, Platform of Technology and Science200 Cambridge Park DriveCambridgeMA 02140USA[email protected]Search for other works by this author on:
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Chapter 8: Engineering Chemistry to Enable Bioactive Small Molecule Discoveryp184-218ByClaudio BattilocchioClaudio BattilocchioSearch for other works by this author on:
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Chapter 9: Genetically Encoded Cyclic Peptide Librariesp219-242ByAli TavassoliAli TavassoliSearch for other works by this author on:
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Chapter 10: Modern Methods for the Synthesis of Carbohydratesp243-274ByRalf Schwoerer;Ralf SchwoererFerrier Research Institute, Victoria University of WellingtonP.O. Box 33436Petone 5046New ZealandSearch for other works by this author on:Martin A. FascioneMartin A. FascioneSearch for other works by this author on:
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Chapter 11: Precursor-directed Biosynthesis and Semi-synthesis of Natural Productsp275-312ByEdward Kalkreuter;Edward KalkreuterComparative Medicine Institute, NC State UniversityRaleighNCUSASearch for other works by this author on:Gavin J. WilliamsGavin J. WilliamsComparative Medicine Institute, NC State UniversityRaleighNCUSASearch for other works by this author on:
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Chapter 12: Site-specific Protein Modification and Bio-orthogonal Chemistryp313-356ByMegan H. WrightMegan H. WrightSearch for other works by this author on:
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Chapter 13: Chemical Protein Synthesis: Strategies and Biological Applicationsp357-397ByManuel M. MüllerManuel M. MüllerSearch for other works by this author on:
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