Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology
Chapter 13: Chemical Protein Synthesis: Strategies and Biological Applications
Published:16 Aug 2018
Special Collection: 2018 ebook collectionSeries: Chemical Biology
Manuel M. Müller, 2018. "Chemical Protein Synthesis: Strategies and Biological Applications", Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, Nick J Westwood, Adam Nelson
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Synthetic protein chemistry enables precise control of the chemical makeup of proteins and facilitates the incorporation of new functionalities and connectivities. This chapter covers the principles of protein synthesis, by solid-phase peptide synthesis one amino acid at a time and through expedient fragment assembly via convergent methods. General applications of synthetic proteins, as well as a series of case studies that demonstrate the utility and versatility of synthetic protein chemistry for solving biological problems are discussed.