Chapter 13: Chemical Protein Synthesis: Strategies and Biological Applications
Published:16 Aug 2018
M. M. Müller, in Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, ed. N. J. Westwood and A. Nelson, The Royal Society of Chemistry, 2018, ch. 13, pp. 357-397.
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Synthetic protein chemistry enables precise control of the chemical makeup of proteins and facilitates the incorporation of new functionalities and connectivities. This chapter covers the principles of protein synthesis, by solid-phase peptide synthesis one amino acid at a time and through expedient fragment assembly via convergent methods. General applications of synthetic proteins, as well as a series of case studies that demonstrate the utility and versatility of synthetic protein chemistry for solving biological problems are discussed.