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Chemical Biology
Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology
Edited by
Nick J Westwood;
Nick J Westwood
University of St Andrews, UK
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Adam Nelson
Adam Nelson
University of Leeds, UK
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Hardback ISBN:
978-1-78262-948-1
PDF ISBN:
978-1-78801-280-5
EPUB ISBN:
978-1-78801-507-3
Special Collection:
2018 ebook collection
Series:
Chemical Biology
No. of Pages:
404
Published online:
16 Aug 2018
Published in print:
28 Aug 2018
Book Chapter
Chapter 8: Engineering Chemistry to Enable Bioactive Small Molecule Discovery
By
Claudio Battilocchio
Claudio Battilocchio
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Published:16 Aug 2018
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Special Collection: 2018 ebook collectionSeries: Chemical Biology
Page range:
184 - 218
Citation
S. V. Ley, D. Fitzpatrick, and C. Battilocchio, in Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, ed. N. J. Westwood and A. Nelson, The Royal Society of Chemistry, 2018, ch. 8, pp. 184-218.
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The chapter describes current methods for automating the chemical synthesis of bioactive small molecules. In particular, the use of the enabling technologies of machine vision, process analytical methods and immobilized systems is highlighted in the context of specific exemplar syntheses. Flow chemistry and advanced automation are likely to find widespread future application in the assembly and discovery of functional small molecules.
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