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Bioactive glass-ceramics (BGCs) are among the biomaterials that elicit a particular biological reaction at the interface of the material, which stimulates cell proliferation, gene response and the formation of a bond between living tissue and the material. Conventionally, BGCs have been tested to fill and restore bone defects, which led to commercial products such as Cerabone®, Biosilicate®, Ceravital® and Bioverite®. This category of biomaterials has become an emerging research field for bone and soft tissue engineering applications. This book chapter outlines the compositions, processing, properties and applications of commercial and promising types of BGCs. Some valuable reports dealing with magnetic BGCs, radiopaque BGCs, composites, coatings, gel-derived BGCs, scaffolds and their relevant issues are reviewed and discussed. It is our hope that this book chapter will provide an insightful summary and discussion on the present and future state of bioactive glass-ceramics, leading to significant innovations in this field.

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