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Chemical Biology
DNA-targeting Molecules as Therapeutic Agents
Edited by
Michael J Waring
Michael J Waring
University of Cambridge, UK
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Hardback ISBN:
978-1-78262-992-4
PDF ISBN:
978-1-78801-292-8
EPUB ISBN:
978-1-78801-428-1
Special Collection:
2018 ebook collection
Series:
Chemical Biology
No. of Pages:
414
Published online:
08 Mar 2018
Published in print:
12 Mar 2018
About this book
There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies.
The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth.
This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
DNA-targeting Molecules as Therapeutic Agents, The Royal Society of Chemistry, 2018.
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Digital access
$223.00
Print format
DNA-targeting Molecules as Therapeutic Agents
$223.00
Table of contents
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Chapter 1: DNA Recognition by Parallel Triplex Formationp1-32ByKeith R. Fox;Keith R. FoxBiological Sciences, Life Sciences Building 85, University of SouthamptonHighfieldSouthampton SO17 1BJUK[email protected][email protected]Search for other works by this author on:Tom Brown;Tom BrownChemistry Research Laboratory, Department of Chemistry, University of OxfordOxford OX1 3TAUK[email protected]Search for other works by this author on:David A. RuslingDavid A. RuslingBiological Sciences, Life Sciences Building 85, University of SouthamptonHighfieldSouthampton SO17 1BJUK[email protected][email protected]Search for other works by this author on:
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Chapter 2: Interfacial Inhibitorsp33-44ByEvgeny Kiselev;Evgeny KiselevDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHBethesdaMDUSA[email protected]Search for other works by this author on:Yves PommierYves PommierDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHBethesdaMDUSA[email protected]Search for other works by this author on:
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Chapter 3: Slow DNA Bindingp45-73ByPer Lincoln;Per LincolnChemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of TechnologyKemivägen 1041296 GothenburgSweden[email protected]Search for other works by this author on:L. Marcus Wilhelmsson;L. Marcus WilhelmssonChemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of TechnologyKemivägen 1041296 GothenburgSweden[email protected]Search for other works by this author on:Bengt NordénBengt NordénChemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of TechnologyKemivägen 1041296 GothenburgSweden[email protected]Search for other works by this author on:
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Chapter 4: Thermal Denaturation of Drug–DNA Complexes1p74-95ByJonathan B. ChairesJonathan B. ChairesJames Graham Brown Cancer Center, University of Louisville505 S. Hancock St.LouisvilleKY 40202USA[email protected]Search for other works by this author on:
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Chapter 5: Computer Simulations of Drug–DNA Interactions: A Personal Journeyp96-143ByFederico GagoFederico GagoArea of Pharmacology, Department of Biomedical Sciences, University of AlcaláE-28871 MadridSpain[email protected]Search for other works by this author on:
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Chapter 6: Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseasesp144-174ByMing-Hon Hou;Ming-Hon HouInstitute of Genomics and Bioinformatics; National Chung Hsing UniversityTaichungTaiwan[email protected]PhD Program in Medical Biotechnology, National Chung Hsing UniversityTaichungTaiwanSearch for other works by this author on:Roshan Satange;Roshan SatangeInstitute of Genomics and Bioinformatics; National Chung Hsing UniversityTaichungTaiwan[email protected]PhD Program in Medical Biotechnology, National Chung Hsing UniversityTaichungTaiwanSearch for other works by this author on:Chung-ke ChangChung-ke ChangInstitute of Biomedical Sciences, Academia SinicaNangangTaipeiTaiwanSearch for other works by this author on:
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Chapter 7: Parsing the Enthalpy–Entropy Compensation Phenomenon of General DNA–Ligand Interactions by a ‘Gradient Determinant’ Approachp175-197ByRobin C. K. Yang;Robin C. K. YangDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Karen L. Kao;Karen L. KaoDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Wen-Chen Yao;Wen-Chen YaoDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Yu-Ling Chen;Yu-Ling ChenDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Chia-Chun Hung;Chia-Chun HungDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Yu-Ting Li;Yu-Ting LiDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Jia-Rong Wu;Jia-Rong WuDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Wei-Kang Hung;Wei-Kang HungDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:Michael J. Waring;Michael J. WaringDepartment of Pharmacology, University of CambridgeTennis Court RoadCambridge CB2 1PDEnglandUKSearch for other works by this author on:Leung ShehLeung ShehDepartment of Chemistry, Tunghai Christian UniversityTaichungTaiwan 407Republic of China[email protected]Search for other works by this author on:
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Chapter 8: Structural Studies of DNA-binding Metal Complexes of Therapeutic Importancep198-227ByJames P. HallJames P. HallDiamond Light SourceHarwell Science and Innovation CampusFermi AvenueDidcot OX11 0DEUKSearch for other works by this author on:
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Chapter 9: Therapeutic Potential of DNA Gene Targeting using Peptide Nucleic Acid (PNA)p228-245ByPeter E. NielsenPeter E. NielsenUniversity of Copenhagen, Department of Cellular and Molecular Medicine, The Panum InstituteBlegdamsvej 3cDK-2200 Copenhagen NDenmark[email protected]Search for other works by this author on:
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Chapter 10: Sequence-selective Interactions of Actinomycin D with DNA: Discovery of a Thermodynamic Switchp246-264ByJason S. Hudson;Jason S. HudsonDepartment of Chemistry, University of Alabama at Birmingham901 14th StreetBirminghamAL 35294USA[email protected]Search for other works by this author on:Aaron Lucius;Aaron LuciusDepartment of Chemistry, University of Alabama at Birmingham901 14th StreetBirminghamAL 35294USA[email protected]Search for other works by this author on:Michael J. Waring;Michael J. WaringDepartment of Biochemistry, Cambridge UniversityCambridge CB2 1GAEnglandUKSearch for other works by this author on:David E. GravesDavid E. GravesDepartment of Chemistry, University of Alabama at Birmingham901 14th StreetBirminghamAL 35294USA[email protected]Search for other works by this author on:
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Chapter 11: Molecular Modelling Approaches for Assessing Quadruplex–Small Molecule Interactionsp265-297ByMartyna Kuta;Martyna KutaLaboratory of Quantum Chemistry, Faculty of ChemistryAdam Mickiewicz UniversityUmultowska Street 89bPoznań 61-614PolandSearch for other works by this author on:Barira Islam;Barira IslamUCL School of Pharmacy, University College London29–39 Brunswick SquareLondon WC1N 1AXUK[email protected]Search for other works by this author on:Shozeb Haider;Shozeb HaiderUCL School of Pharmacy, University College London29–39 Brunswick SquareLondon WC1N 1AXUK[email protected]Search for other works by this author on:Stephen NeidleStephen NeidleUCL School of Pharmacy, University College London29–39 Brunswick SquareLondon WC1N 1AXUK[email protected]Search for other works by this author on:
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Chapter 12: Molecular Recognition of DNA by Py–Im Polyamides: From Discovery to Oncologyp298-331ByPeter B. Dervan;Peter B. DervanDivision of Chemistry and Chemical Engineering, California Institute of TechnologyPasadenaCA 91125USA[email protected]Search for other works by this author on:Alexis A. Kurmis;Alexis A. KurmisDivision of Chemistry and Chemical Engineering, California Institute of TechnologyPasadenaCA 91125USA[email protected]Search for other works by this author on:Paul B. FinnPaul B. FinnDivision of Chemistry and Chemical Engineering, California Institute of TechnologyPasadenaCA 91125USA[email protected]Search for other works by this author on:
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Chapter 13: Synthetic Peptides for DNA Recognition Inspired by Transcription Factorsp332-366ByAnnemieke MadderAnnemieke MadderSearch for other works by this author on:
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Chapter 14: Targeting DNA Mismatches with Coordination Complexesp367-390ByJacqueline K. Barton;Jacqueline K. BartonDivision of Chemistry and Chemical Engineering, California Institute of TechnologyPasadenaCA 91125USA[email protected]Search for other works by this author on:Adam N. Boynton;Adam N. BoyntonDivision of Chemistry and Chemical Engineering, California Institute of TechnologyPasadenaCA 91125USA[email protected]Search for other works by this author on:Kelsey M. BoyleKelsey M. BoyleDivision of Chemistry and Chemical Engineering, California Institute of TechnologyPasadenaCA 91125USA[email protected]Search for other works by this author on:
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Chapter 15: CRISPR Highlights and Transition of Cas9 into a Genome Editing Toolp391-407ByThomas BentinThomas BentinDepartment for Cellular and Molecular Medicine, University of CopenhagenBlegdamsvej 3c2200 Copenhagen NDenmark[email protected]Search for other works by this author on:
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