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Chemical Biology
DNA-targeting Molecules as Therapeutic AgentsCheck Access
Edited by
Michael J Waring
Michael J Waring
University of Cambridge, UK
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Hardback ISBN:
978-1-78262-992-4
PDF ISBN:
978-1-78801-292-8
EPUB ISBN:
978-1-78801-428-1
Special Collection:
2018 ebook collection
Series:
Chemical Biology
No. of Pages:
414
Published online:
08 Mar 2018
Published in print:
12 Mar 2018
Book Chapter
Chapter 5: Computer Simulations of Drug–DNA Interactions: A Personal Journey Check Access
By
Federico Gago
Federico Gago
Area of Pharmacology, Department of Biomedical Sciences, University of Alcalá
E-28871 Madrid
Spain
[email protected]
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Published:08 Mar 2018
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Special Collection: 2018 ebook collectionSeries: Chemical Biology
Page range:
96 - 143
Citation
F. Gago, in DNA-targeting Molecules as Therapeutic Agents, ed. M. J. Waring, The Royal Society of Chemistry, 2018, ch. 5, pp. 96-143.
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This chapter updates much of what was contained in the first edition and includes new material on more tetrahydroisoquinoline antibiotics related to trabectedin, investigating the details of bis-adduct formation with Mitomycin C and a novel study entitled “melting DNA on the computer”. Throughout the emphasis is firmly rooted in computer simulations ‘in silico’ aimed at furnishing evidence of their relevance to experimental studies.
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