Hybrid MR-PET Imaging: Systems, Methods and Applications
The combination of two leading imaging techniques – magnetic resonance imaging and positron emission tomography – is poised to have a large impact and has recently been a driver of research and clinical applications. The hybrid instrument is capable of acquiring both datasets simultaneously and this affords a number of advantages ranging from the obvious, two datasets acquired in the time required for one, through to novel applications. This book describes the basics of MRI and PET and then the technical issues and advantages involved in bringing together the two techniques. Novel applications in preclinical settings, human imaging and tracers are described.
The book is for students and scientists entering the field of MR–PET with an MRI background but lacking PET or vice versa. It provides practical details from experts working in the area.
Hybrid MR-PET Imaging: Systems, Methods and Applications, The Royal Society of Chemistry, 2018.
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CHAPTER 1: Introduction to Magnetic Resonance Imagingp1-44ByW. A. Worthoff;W. A. WorthoffForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:S. D. Yun;S. D. YunForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]JARA-BRAIN – Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityPauwelsstr. 3052074 AachenGermanySearch for other works by this author on:
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CHAPTER 2: MRI Instrumentationp45-63ByJ. Felder;J. FelderForschungszentrum Jülich, Institut of Neuroscience and Medicine - 4Wilhelm-Johnen-Str.Jülich52425Germany[email protected]Search for other works by this author on:C.-H. Choi;C.-H. ChoiForschungszentrum Jülich, Institut of Neuroscience and Medicine - 4Wilhelm-Johnen-Str.Jülich52425Germany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institut of Neuroscience and Medicine - 4Wilhelm-Johnen-Str.Jülich52425Germany[email protected]JARA-BRAIN – Translational MedicineAachenGermanyRWTH Aachen University, Department of NeurologyPauwelsstraße 30Aachen52074GermanySearch for other works by this author on:
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CHAPTER 3: Selective Applications of MRI for the Brainp64-100ByS. D. Yun;S. D. YunForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:E. Farrher;E. FarrherForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:F. Grinberg;F. GrinbergForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:A. M. Oros-Peusquens;A. M. Oros-PeusquensForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]JARA-BRAIN – Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityPauwelsstr. 3052074 AachenGermanySearch for other works by this author on:
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CHAPTER 4: Ultra-high Field Imagingp101-128ByW. A. Worthoff;W. A. WorthoffForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:J. Mauler;J. MaulerForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:A. M. Oros-Peusquens;A. M. Oros-PeusquensForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]JARA-BRAIN – Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityPauwelsstr. 3052074 AachenGermanySearch for other works by this author on:
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CHAPTER 5: Introduction to PETp129-146ByH. Herzog;H. HerzogForschungszentrum Jülich, Institute of Neuroscience and Medicine – 452425 JülichGermany[email protected]Search for other works by this author on:P. AlmeidaP. AlmeidaInstitute of Biophysics and Biomedical Engineering, University of Lisbon1749-016 LisbonPortugalSearch for other works by this author on:
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CHAPTER 6: Positron Emission Tomography Instrumentationp147-161ByC. W. Lerche;C. W. LercheForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:U. Pietrzyk;U. PietrzykForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]University of Wuppertal, Faculty of Mathematics and Natural SciencesGauss-Str. 2042109WuppertalGermanySearch for other works by this author on:M. LenzM. LenzForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]University of Wuppertal, Faculty of Mathematics and Natural SciencesGauss-Str. 2042109WuppertalGermanySearch for other works by this author on:
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CHAPTER 7: PET Quantificationp162-182ByJ. J. Scheins;J. J. ScheinsForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:E. Rota Kops;E. Rota KopsForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:L. Caldeira;L. CaldeiraForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:B. MaB. MaForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:
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CHAPTER 8: Kinetic Modelling and Extraction of Metabolic Parametersp183-202ByH. Herzog;H. HerzogForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:H. Iida;H. IidaDepartment of Investigative Radiology, National Cerebral and Cardiovascular CentreOsakaJapanDepartment of Medical Physics, Turku University Hospital, Department of Biomedicine, University of TurkuTurkuFinlandSearch for other works by this author on:L. CaldeiraL. CaldeiraForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:
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CHAPTER 9: Introduction and Historical Overviewp203-213ByH. Herzog;H. HerzogForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]JARA - BRAIN - Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityAachenGermanySearch for other works by this author on:
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CHAPTER 10: MR-PET Instrumentationp214-228ByC. W. Lerche;C. W. LercheForschungszentrum Jülich, Institute of Neuroscience and Medicine - 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:J. Felder;J. FelderForschungszentrum Jülich, Institute of Neuroscience and Medicine - 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:C.-H. Choi;C.-H. ChoiForschungszentrum Jülich, Institute of Neuroscience and Medicine - 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine - 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]JARA-BRAIN – Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityPauwelsstr. 3052074 AachenGermanySearch for other works by this author on:
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CHAPTER 11: MR-based Corrections for Quantitative PET Imagep229-258ByL. Caldeira;L. CaldeiraForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:E. Rota Kops;E. Rota KopsForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:N. A. da Silva;N. A. da SilvaHospital da Luz Learning Health, Hospital da LuzRua Carlos Alberto da Mota Pinto, Edifício Amoreiras Square 17 – 9º1070-313 LisbonPortugalSearch for other works by this author on:H. HerzogH. HerzogForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:
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CHAPTER 12: Motion Correction in Brain MR-PETp259-272ByR. P. Buschbeck;R. P. BuschbeckForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:L. Caldeira;L. CaldeiraForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:J. Scheins;J. ScheinsForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:L. Tellmann;L. TellmannForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]JARA-BRAIN – Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityPauwelsstr. 3052074 AachenGermanySearch for other works by this author on:
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CHAPTER 13: MR-PET Measurementp273-287ByK.-J. Langen;K.-J. LangenForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Department of Nuclear Medicine, RWTH Aachen University HospitalAachenGermanySearch for other works by this author on:I. Neuner;I. NeunerForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen UniversityAachenGermanyJARA – BRAIN – Translational MedicineGermanySearch for other works by this author on:N. Matela;N. MatelaFacul. de Ciências, IBEB - Inst. de Biofísica e Eng. Biomédica, Univ. de LisboaLisbonPortugalSearch for other works by this author on:E. Rota Kops;E. Rota KopsForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:W. Worthoff;W. WorthoffForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]JARA – BRAIN – Translational MedicineGermanyDepartment of Neurology, RWTH Aachen University HospitalAachenGermanySearch for other works by this author on:
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CHAPTER 14: Parametric Imagingp288-299ByL. Caldeira;L. CaldeiraForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428, JülichGermany[email protected]Search for other works by this author on:H. Herzog;H. HerzogForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428, JülichGermany[email protected]Search for other works by this author on:H. A. Ferreira;H. A. FerreiraInstitute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of LisbonCampo Grande1749-016 LisboaPortugalSearch for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428, JülichGermany[email protected]JARA - BRAIN - Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityAachenGermanySearch for other works by this author on:
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CHAPTER 15: Technical and Methodological Aspects of Whole-body MR-PETp300-316ByJ. Cabello;J. CabelloKlinikum rechts der Isar, Technische Universität München, Nuklearmedizinische Klinik und PoliklinikIsmaninger Straße 22Munich81675Germany[email protected]Search for other works by this author on:F. Schilling;F. SchillingKlinikum rechts der Isar, Technische Universität München, Nuklearmedizinische Klinik und PoliklinikIsmaninger Straße 22Munich81675Germany[email protected]Search for other works by this author on:S. NekollaS. NekollaKlinikum rechts der Isar, Technische Universität München, Nuklearmedizinische Klinik und PoliklinikIsmaninger Straße 22Munich81675Germany[email protected]Search for other works by this author on:
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CHAPTER 16: Brainp317-332ByP. Lohmann;P. LohmannForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:K.-J. Langen;K.-J. LangenForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Department of Nuclear Medicine, RWTH Aachen University HospitalAachenGermanySearch for other works by this author on:N. Galldiks;N. GalldiksForschungszentrum Jülich, Institute of Neuroscience and Medicine – 3Wilhelm-Johnen-Straße 152428 JülichGermanyDepartment of Neurology, University of CologneCologneGermanyCentre of Integrated Oncology (CIO), Universities of Cologne and BonnGermanySearch for other works by this author on:R. Rajkumar;R. RajkumarForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University HospitalAachenGermanySearch for other works by this author on:C. Régio Brambillaa;C. Régio BrambillaaDepartment of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University HospitalAachenGermanySearch for other works by this author on:I. NeunerI. NeunerForschungszentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University HospitalAachenGermanySearch for other works by this author on:
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CHAPTER 17: Clinical Applications of Whole-body MR-PETp333-350ByK. Auf der Springe;K. Auf der SpringeUniversity Hospital Münster, Department of RadiologyAlbert-Schweitzer-Campus 148149 MünsterGermanySearch for other works by this author on:B. Noto;B. NotoUniversity Hospital Münster, Department of Nuclear MedicineAlbert-Schweitzer-Campus 148149 MünsterGermany[email protected]Search for other works by this author on:F. Büther;F. BütherUniversity Hospital Münster, Department of Nuclear MedicineAlbert-Schweitzer-Campus 148149 MünsterGermany[email protected]Search for other works by this author on:M. Wildgruber;M. WildgruberUniversity Hospital Münster, Department of RadiologyAlbert-Schweitzer-Campus 148149 MünsterGermanySearch for other works by this author on:L. SteggerL. SteggerUniversity Hospital Münster, Department of Nuclear MedicineAlbert-Schweitzer-Campus 148149 MünsterGermany[email protected]Search for other works by this author on:
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CHAPTER 18: Preclinical Hybrid MR-PET Scanner Hardwarep351-367ByC.-H. Choi;C.-H. ChoiForschungszentrum Jülich, Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:J. Felder;J. FelderForschungszentrum Jülich, Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:C. W. Lerche;C. W. LercheForschungszentrum Jülich, Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]Search for other works by this author on:N. J. ShahN. J. ShahForschungszentrum Jülich, Neuroscience and Medicine – 4Wilhelm-Johnen-Straße 152428JülichGermany[email protected]JARA – BRAIN – Translational MedicineAachenGermanyDepartment of Neurology, RWTH Aachen UniversityAachenGermanySearch for other works by this author on:
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CHAPTER 19: Preclinical Applications of MR-PETp368-378ByA. Willuweit;A. WilluweitForschunsgzentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-StraßeJülich52425Germany[email protected]Search for other works by this author on:P. Lohmann;P. LohmannForschunsgzentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-StraßeJülich52425Germany[email protected]Search for other works by this author on:C. StegmayrC. StegmayrForschunsgzentrum Jülich, Institute of Neuroscience and Medicine – 4Wilhelm-Johnen-StraßeJülich52425Germany[email protected]Search for other works by this author on:
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CHAPTER 20: Radiotracers for PET and MR-PET Imagingp379-399ByJ. Ermert;J. ErmertForschungszentrum Jülich, Institute of Neuroscience and Medicine – 5Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Search for other works by this author on:B. NeumaierB. NeumaierForschungszentrum Jülich, Institute of Neuroscience and Medicine – 5Wilhelm-Johnen-Straße 152428 JülichGermany[email protected]Institute of Radiochemistry and Experimental Molecular Imaging, University Clinic CologneKerpener Str. 6250937 CologneGermanySearch for other works by this author on:
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