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In this chapter, an overview of the opportunities and challenges of parametric imaging in positron emission tomography (PET) and magnetic resonance (MR) is presented. Parametric imaging, together with the reasons why it is necessary and important, is introduced. In PET, concepts such as dynamic PET and the typical processing steps are explained. The usual parameters obtained through semi-quantitative and quantitative approaches are described. The strength of magnetic resonance imaging is that there are many parameters to be explored and used as contrast generating mechanisms. The challenges involved in MR-PET parametric imaging in a hybrid scanner are also described.

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