CHAPTER 6: Colchicine-, Vinblastine-, Taxol- and Eribulin-based Payloads for Antibody–Drug Conjugates (ADCs)
Published:11 Jul 2019
A. Velani, S. Kay, E. F. Albone, and D. E. Thurston, in Cytotoxic Payloads for Antibody – Drug Conjugates, ed. D. E. Thurston and P. J. M. Jackson, The Royal Society of Chemistry, 2019, pp. 117-136.
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Although payloads based on the auristatins and maytansines are the best-known tubulin inhibitors used in the preparation of antibody–drug conjugates (ADCs), other payloads such as the vinca alkaloids, taxol and its analogues and colchicine have also been utilised. More recently, the tubulin inhibitor eribulin, derived from the marine sponge Halichondria okadai has been developed as an ADC payload, and one ADC based on eribulin (MORAb-202) is presently being evaluated in clinical settings for the treatment of folate-receptor-positive solid tumours.