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Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments
Edited by
Vimal Kumar Jain;
Vimal Kumar Jain
Bhabha Atomic Research Centre, India
Search for other works by this author on:
Hardback ISBN:
978-1-78801-029-0
PDF ISBN:
978-1-78801-190-7
EPUB ISBN:
978-1-78801-223-2
Special Collection:
2017 ebook collection
No. of Pages:
457
Publication date:
26 Sep 2017
About this book
Organoselenium shows incredible promise in medicine, particularly cancer therapy. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications.
Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how organoselenium compound toxicity, redox properties and specificity can be further tuned. The second section explains the biophysics and biochemistry of organoselenium compounds, as well as selenoproteins. The final section closes with several chapters devoted to therapeutic and medicinal applications of organoselenium compounds, covering radioprotectors, anticancer agents and antioxidant behaviour.
With contributions from leading global experts, this book covers recent advances in the field and is an ideal reference for those researching organoselenium compounds.
Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments, The Royal Society of Chemistry, 2017.
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Digital access
$251.00
Print format
Organoselenium Compounds in Biology and Medicine
$251.00
Table of contents
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Chapter 1: An Overview of Organoselenium Chemistry: From Fundamentals to Synthesisp1-33ByVimal K. JainVimal K. JainSearch for other works by this author on:
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Synthetic Advances on Bioactive Selenium CompoundsChapter 2: Looking Beyond the Traditional Idea of Glutathione Peroxidase Mimics as Antioxidantsp35-76ByC. Santi;C. SantiDepartment of Pharmaceutical Sciences, University of PerugiaVia del Liceo 106100PerugiaItaly[email protected]Search for other works by this author on:F. Marini;F. MariniDepartment of Pharmaceutical Sciences, University of PerugiaVia del Liceo 106100PerugiaItaly[email protected]Search for other works by this author on:E. J. LenardãoE. J. LenardãoCentre of Chemical, Pharmaceuticals and Food Sciences, Federal University of PelotasP.O. Box 354CEP 96010-900Pelotas/RSBrazilSearch for other works by this author on:
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Chapter 3: Synthesis of Organoselenium Compounds with Potential Biological Activitiesp77-121ByFateh V. Singh;Fateh V. SinghChemistry Division, SAS, VIT UniversityChennai CampusChennai600 127Tamil NaduIndiaSearch for other works by this author on:Thomas WirthThomas WirthSearch for other works by this author on:
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Chapter 4: The Relevant Chemistry of Imidazoline-2-selone Donors with Potential Biological Applicationsp122-149ByV. LippolisV. LippolisUniversità degli Studi di Cagliari, Dipartimento di Scienze Chimiche e GeologicheS.S. 554 Bivio per SestuMonserrato (CA)09042Italy[email protected]Search for other works by this author on:
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Chapter 5: Organoselenium Cations: Structures, Reactivity and Applicationsp150-177BySangit Kumar;Sangit KumarIndian Institute of Science Education and Research Bhopal, Department of ChemistryBhopal By-Pass Road Bhauri462 066BhopalIndia[email protected]Search for other works by this author on:Harkesh B. SinghHarkesh B. SinghIndian Institute of Technology Bombay, Department of ChemistryPowai, 400 076, MumbaiIndia[email protected]Search for other works by this author on:
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Chapter 6: Organoselenide Fluorophores for Probing Reactive Oxygen Species and Heavy Metalsp178-195BySandip V. Mulay;Sandip V. MulayKorea Advanced Institute of Science and Technology (KAIST), Department of Chemistry373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of Korea[email protected]Institute for Basic Science (IBS), Center for Catalytic Hydrocarbon Functionalizations373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of KoreaSearch for other works by this author on:Youngsam Kim;Youngsam KimKorea Advanced Institute of Science and Technology (KAIST), Department of Chemistry373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of Korea[email protected]Institute for Basic Science (IBS), Center for Catalytic Hydrocarbon Functionalizations373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of KoreaSearch for other works by this author on:Woo Hyun Lee;Woo Hyun LeeKorea Advanced Institute of Science and Technology (KAIST), Department of Chemistry373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of Korea[email protected]Search for other works by this author on:Shubhangi Singh;Shubhangi SinghKorea Advanced Institute of Science and Technology (KAIST), Department of Chemistry373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of Korea[email protected]Search for other works by this author on:David G. ChurchillDavid G. ChurchillKorea Advanced Institute of Science and Technology (KAIST), Department of Chemistry373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of Korea[email protected]Institute for Basic Science (IBS), Center for Catalytic Hydrocarbon Functionalizations373-1 Guseong-dongYuseong-gu, Daejeon305-701Republic of KoreaSearch for other works by this author on:
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Bio-physics, Chemistry and Effect on Oxidative Stress of Organoselenium CompoundsChapter 7: Non-bonded Selenium⋯Heteroatom Interactions in Selenoenzyme Glutathione Peroxidase and Mimicsp197-222ByM. Iwaoka;M. IwaokaTokai University, Department of ChemistryKitakaname, Hiratsuka-shi, Kanagawa 259-1292Japan[email protected]Search for other works by this author on:K. AraiK. AraiTokai University, Department of ChemistryKitakaname, Hiratsuka-shi, Kanagawa 259-1292Japan[email protected]Search for other works by this author on:
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Chapter 8: Carbohydrate-derived Organoselenium Compounds: Synthesis and Application in the Structural Analysis of Biomoleculesp223-253ByChandrababunaidu Kona;Chandrababunaidu KonaGifu University, Department of Applied Bioorganic Chemistry1-1 YanagidoGifu-shi, Gifu 501-1193Japan[email protected]Kyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS)Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501JapanSearch for other works by this author on:Junpei Shimabukuro;Junpei ShimabukuroGifu University, Department of Applied Bioorganic Chemistry1-1 YanagidoGifu-shi, Gifu 501-1193Japan[email protected]Kyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS)Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501JapanSearch for other works by this author on:Makoto Kiso;Makoto KisoGifu University, Department of Applied Bioorganic Chemistry1-1 YanagidoGifu-shi, Gifu 501-1193Japan[email protected]Kyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS)Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501JapanSearch for other works by this author on:Hiromune AndoHiromune AndoGifu University, Department of Applied Bioorganic Chemistry1-1 YanagidoGifu-shi, Gifu 501-1193Japan[email protected]Gifu University, Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN)1-1 YanagidoGifu-shi, Gifu 501-1193JapanKyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS)Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501JapanSearch for other works by this author on:
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Chapter 9: Reaction of Selenium Compounds with Reactive Oxygen Species and the Control of Oxidative Stressp254-276ByLuke D. Carroll;Luke D. CarrollDept. of Biomedical Sciences, Panum Institute, University of CopenhagenBlegdamsvej 3Copenhagen 2200Denmark[email protected]Search for other works by this author on:Michael J. DaviesMichael J. DaviesDept. of Biomedical Sciences, Panum Institute, University of CopenhagenBlegdamsvej 3Copenhagen 2200Denmark[email protected]Search for other works by this author on:
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Chapter 10: Reactive Selenium Species: Redox Modulation, Antioxidant, Antimicrobial and Anticancer Activitiesp277-302ByMuhammad Jawad Nasim;Muhammad Jawad NasimDivision of Bioorganic Chemistry, School of Pharmacy, Saarland UniversityCampus B 2.1D-66123 SaarbrueckenGermany[email protected][email protected][email protected]Search for other works by this author on:Wesam Ali;Wesam AliDivision of Bioorganic Chemistry, School of Pharmacy, Saarland UniversityCampus B 2.1D-66123 SaarbrueckenGermany[email protected][email protected][email protected]Search for other works by this author on:Enrique Domínguez-Álvarez;Enrique Domínguez-ÁlvarezInstituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC)Juan de la Cierva, 328006MadridSpain[email protected]Search for other works by this author on:Eufranio N. da Silva Júnior;Eufranio N. da Silva JúniorInstitute of Exact Sciences, Department of Chemistry, Federal University of Minas GeraisBelo HorizonteMG 31270-901Brazil[email protected]Search for other works by this author on:Rahman Shah Zaib Saleem;Rahman Shah Zaib SaleemDepartment of Chemistry, School of Sciences and Engineering, Lahore University of Management SciencesOpposite Sector-U, DHALahore54792Pakistan[email protected]Search for other works by this author on:Claus JacobClaus JacobDivision of Bioorganic Chemistry, School of Pharmacy, Saarland UniversityCampus B 2.1D-66123 SaarbrueckenGermany[email protected][email protected][email protected]Search for other works by this author on:
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Chapter 11: Ebselen and Thioredoxin Systems in Human Health, Disease and Therapeutic Potentialp303-316ByJun Lu;Jun LuSchool of Pharmaceutical Sciences, Southwest University400715 ChongqingChinaDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska InstitutetSE-171 77 StockholmSweden[email protected][email protected][email protected]Search for other works by this author on:Xiaoyuan Ren;Xiaoyuan RenDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska InstitutetSE-171 77 StockholmSweden[email protected][email protected][email protected]Search for other works by this author on:Lili Zou;Lili ZouDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska InstitutetSE-171 77 StockholmSweden[email protected][email protected][email protected]Search for other works by this author on:Arne HolmgrenArne HolmgrenDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska InstitutetSE-171 77 StockholmSweden[email protected][email protected][email protected]Search for other works by this author on:
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Therapeutic Applications of Organoselenium CompoundsChapter 12: History and Development of Selenium-based Radioprotectors: Distinctions between the Inorganic and Organic Formsp317-341ByA. Kunwar;A. KunwarRadiation & Photochemistry DivisionBhabha Atomic Research Centre, Mumbai – 400085India[email protected][email protected]Homi Bhabha National Institute, Bhabha Atomic Research CentreMumbai – 400085IndiaSearch for other works by this author on:K. I. PriyadarsiniK. I. PriyadarsiniChemistry DivisionBhabha Atomic Research Centre, Mumbai – 400085IndiaHomi Bhabha National Institute, Bhabha Atomic Research CentreMumbai – 400085IndiaSearch for other works by this author on:
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Chapter 13: Toxicology and Anticancer Activity of Synthetic Organoselenium Compoundsp342-376ByJoão B. T. Rocha;João B. T. RochaUniversidade Federal de Santa Maria, Departamento de Bioquímica e Biologia MolecularAv Roraiman° 1000Santa Maria97090-900Brazil[email protected]Search for other works by this author on:Cláudia S. Oliveira;Cláudia S. OliveiraUniversidade Federal de Santa Maria, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaAv Roraiman° 1000Santa Maria97090-900BrazilSearch for other works by this author on:Pablo A. NogaraPablo A. NogaraUniversidade Federal de Santa Maria, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaAv Roraiman° 1000Santa Maria97090-900BrazilSearch for other works by this author on:
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Chapter 14: Metabolism of Selenium/Selenocystine and Their Roles in the Prevention and Treatment of Human Cancerp377-400BySougat Misra;Sougat MisraDivision of Pathology F46, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholmSweden 141 86[email protected]Search for other works by this author on:Mikael BjörnstedtMikael BjörnstedtDivision of Pathology F46, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholmSweden 141 86[email protected]Search for other works by this author on:
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Chapter 15: Organoselenium Compounds as Cancer Therapeutic Agentsp401-435ByValentina Gandin;Valentina GandinDepartment of Pharmaceutical and Pharmacological Sciences, University of PadovaVia Marzolo 535131 PadovaItaly[email protected]Search for other works by this author on:Aristi P. FernandesAristi P. FernandesDivision of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska InstitutetSE-171 77 StockholmSweden[email protected]Search for other works by this author on:
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Chapter 16: Cancer Prevention by Different Forms of Seleniump436-451ByA. M. DiamondA. M. DiamondUniversity of Illinois at Chicago, Department of Pathology840 South Wood StreetChicagoIllinois60612USA[email protected]Search for other works by this author on:
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