Paramagnetism in Experimental Biomolecular NMR
Chapter 3: Structural and Dynamic Characterization of Protein Domains using Paramagnetic Data
Published:03 Aug 2018
J. H. Prestegard and M. J. Rogals, in Paramagnetism in Experimental Biomolecular NMR, ed. C. Luchinat, G. Parigi, and E. Ravera, The Royal Society of Chemistry, 2018, ch. 3, pp. 85-106.
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This chapter highlights paramagnetic effects that have proven useful in the structural and dynamic characterization of proteins, particularly pseudocontact shifts (PCSs), paramagnetic relaxation enhancements (PREs), and field-induced residual dipolar couplings (RDCs). It discusses how these effects are implemented in commonly used structure determination and analysis software, and it gives examples of application where they have made particularly unique contributions to structural characterization.