Skip to Main Content
Skip Nav Destination

Small co-solute molecules containing unpaired electrons can impart strong perturbations on nuclear shielding and nuclear relaxation of dissolved compounds, and thereby form a potent class of non-covalent probes for molecular science. These paramagnetic co-solutes range from exquisite lanthanoid and transition metal complexes to a molecule as simple as dioxygen. In this chapter, we discuss the various effects that can be observed due to paramagnetic co-solutes, and we highlight how these effects have spurred the buildout of their application to protein science. For example, dioxygen is a very sensitive probe able to identify internal cavities in proteins, whereas neutral gadolinium chelates have become key in the structure determination of protein complexes in solution.

You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal