Capillary Electrophoresis – Mass Spectrometry for Metabolomics
CHAPTER 7: CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications
Published:12 Jul 2018
Akiyoshi Hirayama, Tomoyoshi Soga, 2018. "CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications", Capillary Electrophoresis – Mass Spectrometry for Metabolomics, Rawi Ramautar
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The metabolome is defined as the total set of low molecular weight compounds (generally less than 1.5 kDa) that exist in biological samples. Metabolomics (or metabolome analysis), together with genomics, transcriptomics and proteomics, is one of the main “omics” technologies in systems biology. Therefore, metabolomics has become an important research field for gaining functional insight into cell biology. In particular, metabolites are the final products in biological systems, and their variations are thought to reflect the responses caused by a number of metabolic perturbations. Currently, the human metabolome database lists 74 461 metabolites (as of July 1, 2017),1 but...