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Despite the not-so-straightforward coupling of chiral capillary electrophoresis (CE) to mass spectrometry (MS), this approach has been shown to offer numerous possibilities in the past few years. The applicability of chiral CE-MS to the emerging metabolomics field has not been exploited in full detail yet. In this context, the application of CE-MS for chiral metabolomics has only been focused on targeted studies, mainly for the investigation of the enantioselective metabolism of drugs and/or other molecules. This indicates that non-targeted studies have not yet been implemented using this technique. This work discusses those targeted contributions using CE-MS for chiral metabolic profiling studies. In addition, potential strategies to carry out studies of metabolic profiles are included. Future trends should involve improvement in robustness and sensitivity, and development of new chiral selectors compatible with MS detection. These improvements are expected to open up new possibilities for a more solid implementation of CE-MS in chiral metabolomics.

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