Capillary Electrophoresis – Mass Spectrometry for Metabolomics
CHAPTER 9: Potential of CE-MS for Chiral Metabolic Profiling
Published:12 Jul 2018
Elena Sánchez-López, María Luisa Marina, Antonio L. Crego, 2018. "Potential of CE-MS for Chiral Metabolic Profiling", Capillary Electrophoresis – Mass Spectrometry for Metabolomics, Rawi Ramautar
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Chirality is an inherent property of every biological system, including the basic building blocks of life (amino acids and sugars), and larger molecules derived from them, such as peptides, proteins, and polysaccharides.1 Therefore, it is of utmost importance to ensure adequate chiral separation in order to be able to deepen the existing knowledge on chiral systems. This chapter describes the potential of the coupling of CE to MS to carry out chiral metabolic profiling. With this aim, the interest in chirality and its relevance, chiral separation in CE, the specific strategies to be successful in chiral CE-MS coupling, and...