Stimuli-responsive Drug Delivery Systems
The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.
Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
Stimuli-responsive Drug Delivery Systems, The Royal Society of Chemistry, 2018.
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Table of contents
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CHAPTER 1: Fundamentals of Stimuli-responsive Drug and Gene Delivery Systemsp1-32ByVladimir P. TorchilinVladimir P. TorchilinNortheastern University, Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine360 Huntington Ave, 02115Boston02151USAv.torchilin@northeastern.eduSearch for other works by this author on:
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CHAPTER 2: Materials and Chemistry of Stimuli-responsive Drug Delivery Systemsp33-50ByMeghana RawalMeghana RawalSearch for other works by this author on:
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CHAPTER 3: pH-responsive Drug Delivery Systemsp51-82ByZhaohui Wang;Zhaohui WangDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas5323 Harry Hines BlvdDallasTX 75390USAjinming.gao@utsouthwestern.eduSearch for other works by this author on:Xinyi Zhang;Xinyi ZhangDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas5323 Harry Hines BlvdDallasTX 75390USAjinming.gao@utsouthwestern.eduSearch for other works by this author on:Gang Huang;Gang HuangDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas5323 Harry Hines BlvdDallasTX 75390USAjinming.gao@utsouthwestern.eduSearch for other works by this author on:Jinming GaoJinming GaoDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas5323 Harry Hines BlvdDallasTX 75390USAjinming.gao@utsouthwestern.eduSearch for other works by this author on:
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CHAPTER 4: Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tractp83-108ByAndreia Almeida;Andreia AlmeidaInstituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalbruno.sarmento@ineb.up.ptInstituto de Engenharia Biomédica (INEB), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalInstituto Ciências Biomédicas Abel Salazar (ICBAS), Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugalSearch for other works by this author on:Helena Macedo;Helena MacedoInstituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalbruno.sarmento@ineb.up.ptInstituto de Engenharia Biomédica (INEB), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalInstituto Ciências Biomédicas Abel Salazar (ICBAS), Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugalSearch for other works by this author on:José das Neves;José das NevesInstituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalbruno.sarmento@ineb.up.ptInstituto de Engenharia Biomédica (INEB), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalSearch for other works by this author on:Bruno SarmentoBruno SarmentoInstituto de Investigação e Inovação em Saúde (i3S), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalbruno.sarmento@ineb.up.ptInstituto de Engenharia Biomédica (INEB), Universidade do PortoRua Alfredo Allen, 2084200-393 PortoPortugalCESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da SaúdeRua Central de Gandra 13174585-116 GandraPortugalSearch for other works by this author on:
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CHAPTER 5: Redox-responsive Drug Delivery Systemsp109-144ByArchana Bhaw-Luximon;Archana Bhaw-LuximonBiomaterials, Drug Delivery and Nanotechnology Unit, Centre for Biomedical and Biomaterials Research (CBBR), University of MauritiusRéduitMauritiusa.luximon@uom.ac.mudjhurry@uom.ac.muSearch for other works by this author on:Dhanjay JhurryDhanjay JhurryBiomaterials, Drug Delivery and Nanotechnology Unit, Centre for Biomedical and Biomaterials Research (CBBR), University of MauritiusRéduitMauritiusa.luximon@uom.ac.mudjhurry@uom.ac.muSearch for other works by this author on:
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CHAPTER 6: Magnetically-responsive DDSp145-162ByE. Guisasola;E. GuisasolaDpto. Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0 28029MadridSpainvallet@ucm.esSearch for other works by this author on:A. Baeza;A. BaezaDpto. Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0 28029MadridSpainvallet@ucm.esSearch for other works by this author on:M. ValletM. ValletDpto. Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)Av. Monforte de Lemos, 3-5, Pabellón 11, Planta 0 28029MadridSpainvallet@ucm.esSearch for other works by this author on:
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CHAPTER 7: Light-responsive Drug Delivery Systemsp163-191ByX. Tan;X. TanNortheastern University, Department of Chemistry and Chemical Biology360 Huntington Ave.BostonMA 02115USAk.zhang@northeastern.eduSearch for other works by this author on:E. L. Burchfield;E. L. BurchfieldNortheastern University, Department of Chemistry and Chemical Biology360 Huntington Ave.BostonMA 02115USAk.zhang@northeastern.eduSearch for other works by this author on:K. ZhangK. ZhangNortheastern University, Department of Chemistry and Chemical Biology360 Huntington Ave.BostonMA 02115USAk.zhang@northeastern.eduSearch for other works by this author on:
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CHAPTER 8: Integrated Polymer Composites for Electro-responsive Drug Deliveryp192-208ByP. Pradeep;P. PradeepWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the WitwatersrandJohannesburgSouth Africaviness.pillay@wits.ac.zaSearch for other works by this author on:P. Kumar;P. KumarWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the WitwatersrandJohannesburgSouth Africaviness.pillay@wits.ac.zaSearch for other works by this author on:Y. E. Choonara;Y. E. ChoonaraWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the WitwatersrandJohannesburgSouth Africaviness.pillay@wits.ac.zaSearch for other works by this author on:V. PillayV. PillayWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the WitwatersrandJohannesburgSouth Africaviness.pillay@wits.ac.zaSearch for other works by this author on:
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CHAPTER 9: Enzyme-responsive Drug Delivery Systemsp209-231ByEmilie Secret;Emilie SecretDept. of Materials Science and Engineering, University of FloridaGainesvilleFLUSAjandrew@mse.ufl.eduSearch for other works by this author on:Jennifer S. AndrewJennifer S. AndrewDept. of Materials Science and Engineering, University of FloridaGainesvilleFLUSAjandrew@mse.ufl.eduSearch for other works by this author on:
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CHAPTER 10: Swelling-controlled Drug Delivery Systemsp232-264ByCandace Minhthu Day;Candace Minhthu DayCentre for Pharmaceutical Innovation and Development, School of Pharmacy and Medical Science, University of South AustraliaAdelaideSA 5000AustraliaSanjay.Garg@unisa.edu.auSearch for other works by this author on:Thomas G. Barclay;Thomas G. BarclayCentre for Pharmaceutical Innovation and Development, School of Pharmacy and Medical Science, University of South AustraliaAdelaideSA 5000AustraliaSanjay.Garg@unisa.edu.auSearch for other works by this author on:Yunmei Song;Yunmei SongCentre for Pharmaceutical Innovation and Development, School of Pharmacy and Medical Science, University of South AustraliaAdelaideSA 5000AustraliaSanjay.Garg@unisa.edu.auSearch for other works by this author on:Sanjay GargSanjay GargCentre for Pharmaceutical Innovation and Development, School of Pharmacy and Medical Science, University of South AustraliaAdelaideSA 5000AustraliaSanjay.Garg@unisa.edu.auSearch for other works by this author on:
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CHAPTER 11: Biologically-inspired Stimuli-responsive DDSp265-283ByJeong-Hwan KimJeong-Hwan KimYokohama City University, Graduate School of Medicine3-9 Fukuura, Kanazawa-kuYokohama236-0004Japanbiohalo@gmail.comSearch for other works by this author on:
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CHAPTER 12: Stimuli-responsive Materials in Theranosticsp284-316ByHao Wu;Hao WuDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisSacramentoCA 95817USAkslam@ucdavis.eduSearch for other works by this author on:Lu Zhang;Lu ZhangDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisSacramentoCA 95817USAkslam@ucdavis.eduSearch for other works by this author on:Yuanpei Li;Yuanpei LiDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisSacramentoCA 95817USAkslam@ucdavis.eduSearch for other works by this author on:Kit S. LamKit S. LamDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisSacramentoCA 95817USAkslam@ucdavis.eduDepartment of Internal Medicine, Division of Hematology/Oncology, University of California DavisSacramentoCA 95817USAlypli@ucdavis.eduSearch for other works by this author on:
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CHAPTER 13: Stimuli-responsive Material Inspired Drug Delivery Systems and Devicesp317-334ByShivaprasad Manchineella;Shivaprasad ManchineellaBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)JakkurBengaluru560064KarnatakaIndiatgraju@jncasr.ac.inSearch for other works by this author on:Thimmaiah GovindarajuThimmaiah GovindarajuBioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)JakkurBengaluru560064KarnatakaIndiatgraju@jncasr.ac.inSearch for other works by this author on:
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CHAPTER 14: Regulatory and Commercialization Challenges with Stimuli-responsive Nanomedicinesp335-354ByAmit Singh;Amit SinghAllexcel Inc.135 Wood St.West HavenConnecticutUSA 06516Search for other works by this author on:Mansoor M. AmijiMansoor M. AmijiDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University360 Huntington Avenue – 140 TFBostonMassachusettsUSA 02115m.amiji@neu.eduSearch for other works by this author on:
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