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Magnetic-responsive drug delivery systems have received great attention due to the possibility of building theranostic systems. The application of a non-invasive external stimuli as a magnetic field that also allows the imaging and localization of the devices and the release of therapeutic drugs means a great opportunity for the development of new treatments to prevent diseases such as cancer. This chapter will focus on smart materials based on magnetic nanoparticles that have been studied for the formulation of such delivery systems and their synergic effect in combination with drugs for potential applications in the biomedical field. In addition, the possibility of applying hyperthermia at the macro and nanoscale levels and their implications will be discussed.

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