CHAPTER 4: The Skin Aging Exposome

The totality of non-genetic, mainly environmental factors a human being is exposed to from conception to death is summarized by the term ‘exposome’. This exposome concept aims to better understand the influence of all external and internal factors, their interaction with each other and with genetic factors on the human body. Skin is a barrier organ and thus research on the skin exposome is of obvious relevance. In this state-of-the-art review, we summarize existing information on the skin exposome by focusing on skin aging as a trait present in healthy skin.