CHAPTER 10: New Scans and Resources in Lipidomics
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Published:13 Jan 2020
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Special Collection: 2020 ebook collection
W. J. Griffiths and Y. Wang, in Lipidomics: Current and Emerging Techniques, ed. W. Griffiths and Y. Wang, The Royal Society of Chemistry, 2020, pp. 263-282.
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In the 1970s and 1980s, lipidomics existed but under the guise of “metabolite profiling”, largely performed on gas chromatography – mass spectrometry (GC-MS) instruments or using fast atom bombardment (FAB) ionisation on high-resolution magnetic sector MS instruments. Today, lipidomics has become a field of study in its own right with electrospray as the dominating ionisation mode, i.e. ESI-MS, often linked with online chromatographic separation and tandem mass spectrometry (MS/MS). In this chapter we will discuss some of the newer scan modes available on modern instruments made possible by fast scanning and high-resolution with accurate mass measurement.