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Chemical Biology
Synthetic Glycomes
Edited by
Peng George Wang
Peng George Wang
Georgia State University , USA
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Hardback ISBN:
978-1-78801-164-8
PDF ISBN:
978-1-78801-657-5
EPUB ISBN:
978-1-78801-777-0
Special Collection:
2019 ebook collection
Series:
Chemical Biology
No. of Pages:
469
Published online:
08 Apr 2019
Published in print:
23 Apr 2019
Book Chapter
CHAPTER 7: Chemical Synthesis of Glycopeptides and Glycoproteins
By
Nikesh Narang
;
Nikesh Narang
Osaka University, Department of Chemistry
1-1 Machikaneyama
Toyonaka
560-0043
Japan
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Rohit K. Sharma
;
Rohit K. Sharma
Panjab University, Department of Chemistry & Centre of Advanced Studies
Sector-14
160014
Chandigarh
India
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Hironobu Hojo
Hironobu Hojo
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Published:08 Apr 2019
-
Special Collection: 2019 ebook collectionSeries: Chemical Biology
Page range:
151 - 171
Citation
N. Narang, R. K. Sharma, and H. Hojo, in Synthetic Glycomes, ed. W. Guan, L. Li, and P. G. Wang, The Royal Society of Chemistry, 2019, pp. 151-171.
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In this chapter, recent progress in the chemical synthesis of glycoprotein is briefly summarized. Starting from the solid-phase synthesis of glycopeptide, the synthetic method for the glycosylated peptide thioester, which is the key intermediate for glycoprotein synthesis by the ligation method, is described. The results of several O- and N-linked glycoprotein syntheses are then exemplified to show the efficiency of the ligation method.
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