CHAPTER 14: Solid-phase Glycan Synthesis
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Published:08 Apr 2019
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Special Collection: 2019 ebook collectionSeries: Chemical Biology
F. Pfrengle, in Synthetic Glycomes, ed. W. Guan, L. Li, and P. G. Wang, The Royal Society of Chemistry, 2019, pp. 331-355.
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Researchers in glycobiology depend on the availability of pure and structurally well-defined glycans that are provided by chemical synthesis. Solid-phase synthesis offers attractive access to these glycans as no intermediary purification steps are required during their assembly. Particularly the automation of solid-phase glycan synthesis (automated glycan assembly) has enabled the procurement of large numbers of complex glycans in a short space of time. Recently, significant progress has been made in producing glycans of increasing lengths or containing synthetically difficult glycosidic linkages. This chapter gives an introduction to solid-phase glycan synthesis and summarizes selected syntheses of complex oligosaccharides, with a particular focus on recent advances in the automated glycan assembly of mammalian, bacterial, and plant glycans.