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Chemical Biology
Synthetic Glycomes
Edited by
Peng George Wang
Peng George Wang
Georgia State University , USA
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Hardback ISBN:
978-1-78801-164-8
PDF ISBN:
978-1-78801-657-5
EPUB ISBN:
978-1-78801-777-0
Special Collection:
2019 ebook collection
Series:
Chemical Biology
No. of Pages:
469
Published online:
08 Apr 2019
Published in print:
23 Apr 2019
Book Chapter
CHAPTER 6: Chemoenzymatic Synthesis of α-Dystroglycan O-Mannose Glycans
By
Caicai Meng
;
Caicai Meng
National Glycoengineering Research Center and School of Pharmaceutical Science, Shandong University
Jinan 250012
China
[email protected]
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Chang-Cheng Liu
;
Chang-Cheng Liu
National Glycoengineering Research Center and School of Pharmaceutical Science, Shandong University
Jinan 250012
China
[email protected]State Key Laboratory of Microbial Technology, Shandong University
Jinan 250100
China
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Hongzhi Cao
Hongzhi Cao
National Glycoengineering Research Center and School of Pharmaceutical Science, Shandong University
Jinan 250012
China
[email protected]State Key Laboratory of Microbial Technology, Shandong University
Jinan 250100
China
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Published:08 Apr 2019
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Special Collection: 2019 ebook collectionSeries: Chemical Biology
Page range:
125 - 150
Citation
C. Meng, C. Liu, and H. Cao, in Synthetic Glycomes, ed. W. Guan, L. Li, and P. G. Wang, The Royal Society of Chemistry, 2019, pp. 125-150.
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O-mannosylation is a conserved common post-translational modification of various eukaryotic proteins. The O-mannose glycans account for up to 30% of total O-glycans in mammalian brain tissues. However, the α-dystroglycan (α-DG) is the only O-mannosylated protein that has been extensively studied. This review covers the biosynthetic pathways and biological roles of O-mannose glycans, as well as the chemical and chemoenzymatic strategies developed for the synthesis of O-mannose core M1, core M2 and core M3 glycans.
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