CHAPTER 4: Chemical Synthesis of N-Glycans Check Access

Glycosylation is an important protein modification in nature that controls many biological processes. More than 50% of human proteins are glycosylated through asparagine residues. However, acquiring those N-glycans from natural sources is often laborious. Chemical synthesis, therefore, is a worthwhile alternative. This chapter summarizes recent advances in chemical synthesis, including strategies toward high-mannose type, hybrid type, complex type, N-acetylneuraminic acid (Neu5Ac)-containing, asymmetric, bisecting and core-fucosylated N-glycans.