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Chemical Biology
Synthetic Glycomes
Edited by
Peng George Wang
Peng George Wang
Georgia State University , USA
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Hardback ISBN:
978-1-78801-164-8
PDF ISBN:
978-1-78801-657-5
EPUB ISBN:
978-1-78801-777-0
Special Collection:
2019 ebook collection
Series:
Chemical Biology
No. of Pages:
469
Published online:
08 Apr 2019
Published in print:
23 Apr 2019
Book Chapter
CHAPTER 8: Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides
By
Sherif Ramadan
;
Sherif Ramadan
Department of Chemistry, Michigan State University
578 South Shaw Lane
East Lansing
MI 48824
USA
[email protected]Chemistry Department, Faculty of Science, Benha University
Benha
Qaliobiya 13518
Egypt
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Weizhun Yang
;
Weizhun Yang
Department of Chemistry, Michigan State University
578 South Shaw Lane
East Lansing
MI 48824
USA
[email protected]
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Xuefei Huang
Xuefei Huang
Department of Chemistry, Michigan State University
578 South Shaw Lane
East Lansing
MI 48824
USA
[email protected]Department of Biomedical Engineering, Michigan State University
East Lansing
MI 48824
USA
Institute for Quantitative Health Science and Engineering, Michigan State University
East Lansing
MI 48824
USA
https://www2.chemistry.msu.edu/faculty/huang/
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-
Published:08 Apr 2019
-
Special Collection: 2019 ebook collectionSeries: Chemical Biology
Page range:
172 - 206
Citation
S. Ramadan, W. Yang, and X. Huang, in Synthetic Glycomes, ed. W. Guan, L. Li, and P. G. Wang, The Royal Society of Chemistry, 2019, pp. 172-206.
Download citation file:
Chondroitin sulfate (CS) and chondroitin sulfate proteoglycan (CSPG) belong to the glycosaminoglycan (GAG) family, a class of poly-anionic glyco-conjugates widely expressed by animal cells. They play important roles in many biological events. Here, we summarize the main considerations in the design of chemical and enzymatic methodologies to access diverse CS structures with well-defined sulfation patterns. In addition, generation of CS polymers and conjugates are reviewed. Finally, syntheses of CS glycopeptides towards CSPGs are discussed.
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