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Drug Discovery
Protein – Protein Interaction Regulators
Edited by
Haian Fu
Haian Fu
Emory University School of Medicine, USA
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Hardback ISBN:
978-1-78801-187-7
PDF ISBN:
978-1-78801-654-4
EPUB ISBN:
978-1-83916-050-9
Special Collection:
2020 ebook collection
Series:
Drug Discovery Series
No. of Pages:
380
Published online:
14 Dec 2020
Published in print:
15 Dec 2020
Book Chapter
CHAPTER 10: Small-molecule Modulators of Protein–Protein Interactions: Focus on 14-3-3 PPIs
By
L. Iralde-Lorente
;
L. Iralde-Lorente
Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena
Siena
Italy
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M. Botta
;
M. Botta
Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena
Siena
Italy
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C. Ottmann
C. Ottmann
Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit Eindhoven
Den Dolech 2
5612 AZ Eindhoven
The Netherlands
[email protected]Department of Chemistry, University of Duisburg-Essen
Universitätsstraße 7
45117
Essen
Germany
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Published:14 Dec 2020
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Special Collection: 2020 ebook collectionSeries: Drug Discovery Series
Page range:
249 - 279
Citation
L. Iralde-Lorente, M. Botta, and C. Ottmann, in Protein – Protein Interaction Regulators, ed. S. Roy and H. Fu, The Royal Society of Chemistry, 2020, pp. 249-279.
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Small-molecule modulation of protein–protein interactions (PPIs) is one of the most promising approaches for drug discovery and chemical biology. In this chapter we give a brief overview of some important concepts and examples with a focus on modulators of binding of the adaptor protein 14-3-3 to its multitude of targets, many of which are of high medical relevance.
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