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Drug Discovery
Protein – Protein Interaction Regulators
Edited by
Haian Fu
Haian Fu
Emory University School of Medicine, USA
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Hardback ISBN:
978-1-78801-187-7
PDF ISBN:
978-1-78801-654-4
EPUB ISBN:
978-1-83916-050-9
Special Collection:
2020 ebook collection
Series:
Drug Discovery
No. of Pages:
380
Published online:
14 Dec 2020
Published in print:
15 Dec 2020
Book Chapter
CHAPTER 3: High Throughput Screening Methods for PPI Inhibitor Discovery
By
Sean P. Doyle
;
Sean P. Doyle
Molecular and Systems Pharmacology Graduate Program, Emory University
Atlanta
GA 30322
USA
[email protected]Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Atlanta
GA 30322
USA
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Xiulei Mo
;
Xiulei Mo
Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Atlanta
GA 30322
USA
Emory Chemical Biology Discovery Center, Emory University School of Medicine
Atlanta
GA 30322
USA
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Kun Qian
;
Kun Qian
Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Atlanta
GA 30322
USA
Emory Chemical Biology Discovery Center, Emory University School of Medicine
Atlanta
GA 30322
USA
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Danielle N. Cicka
;
Danielle N. Cicka
Molecular and Systems Pharmacology Graduate Program, Emory University
Atlanta
GA 30322
USA
[email protected]Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Atlanta
GA 30322
USA
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Qiankun Niu
;
Qiankun Niu
Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Atlanta
GA 30322
USA
Emory Chemical Biology Discovery Center, Emory University School of Medicine
Atlanta
GA 30322
USA
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Haian Fu
Haian Fu
Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Atlanta
GA 30322
USA
Emory Chemical Biology Discovery Center, Emory University School of Medicine
Atlanta
GA 30322
USA
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Published:14 Dec 2020
-
Special Collection: 2020 ebook collectionSeries: Drug Discovery
Page range:
49 - 86
Citation
S. P. Doyle, X. Mo, K. Qian, D. N. Cicka, Q. Niu, and H. Fu, in Protein – Protein Interaction Regulators, ed. S. Roy and H. Fu, The Royal Society of Chemistry, 2020, pp. 49-86.
Download citation file:
As the importance of protein–protein interactions (PPIs) in human health and disease has become broadly recognized, interest in identifying inhibitors of PPIs has increased substantially. High throughput screening (HTS) is one of several strategies that have been implemented to identify PPI inhibitors. In this chapter, HTS methods are surveyed and situated within the broader context of PPI inhibitor discovery.
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