CHAPTER 2: Protein–Protein Interaction Networks in Human Disease

Protein–protein interactions (PPIs) are a foundational life process. Much work over the past few decades has uncovered countless roles that protein–protein interactions play in both health and disease. Most of this work examined the interactions between only two proteins at a time. Recently, however, there has been a surge of research examining entire networks of PPIs in disease conditions. This chapter covers the basic principles of PPI network analysis, methodologies commonly employed to generate PPI networks, and the role that PPI network analysis plays in diverse diseases, including cancer, diabetes, and neurodegenerative diseases, among others.