CHAPTER 13: Nucleic Acid Innate Immune Receptors

Viral infection is a serious threat to humans. Nucleic acid (NA) sensing is an essential strategy to protect humans from viral infection. Currently, many intracellular NA sensors for DNA and RNA have been identified. To control viral infections, the immune system uses a variety of NA sensors, including Toll-like receptors in endolysosomes and cytosolic NA sensors. These sensors activate defence responses by inducing the production of a variety of cytokines, including type I interferons and interleukin-1 beta (IL-1β). In addition to viral NAs, self-derived NAs are released during tissue damage and activate NA sensors, which leads to a variety of inflammatory diseases. To avoid unnecessary activation of NA sensors, the processing and trafficking of NA sensors and NAs needs to be tightly controlled. The regulatory mechanisms of NA sensors and NAs have been clarified by biochemical, cell biological, and crystal structure analyses. Here, we summarize recent progress on the mechanisms controlling NA sensor activation.