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New Developments in NMR
In-cell NMR Spectroscopy: From Molecular Sciences to Cell Biology
Edited by
Yutaka Ito;
Yutaka Ito
Tokyo Metropolitan University, Japan
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Masahiro Shirakawa
Masahiro Shirakawa
Kyoto University, Japan
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Hardback ISBN:
978-1-78801-217-1
PDF ISBN:
978-1-78801-307-9
EPUB ISBN:
978-1-83916-093-6
Special Collection:
2019 ebook collection
Series:
New Developments in NMR
No. of Pages:
305
Publication date:
09 Dec 2019
Book Chapter
Chapter 15: Primary Drug Screening by In-cell NMR Spectroscopy
By
Stephen Dansereau
;
Stephen Dansereau
Department of Chemistry, University at Albany, State University of New York
1400 Washington Ave.
Albany
NY 12222
USA
[email protected]
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David S. Burz
;
David S. Burz
Department of Chemistry, University at Albany, State University of New York
1400 Washington Ave.
Albany
NY 12222
USA
[email protected]
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Alexander Shekhtman
Alexander Shekhtman
Department of Chemistry, University at Albany, State University of New York
1400 Washington Ave.
Albany
NY 12222
USA
[email protected]
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Published:09 Dec 2019
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Special Collection: 2019 ebook collectionSeries: New Developments in NMR
Page range:
249 - 271
Citation
S. Dansereau, D. S. Burz, and A. Shekhtman, in In-cell NMR Spectroscopy: From Molecular Sciences to Cell Biology, ed. Y. Ito, V. Dötsch, and M. Shirakawa, The Royal Society of Chemistry, 2019, ch. 15, pp. 249-271.
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The successful application of in-cell NMR spectroscopy for primary drug high-throughput screening (HTS), by direct and indirect target engagement in prokaryotes is reviewed. We discuss approaches for identifying drug-binding targets, mapping the target interaction surface and methodologies to rapidly screen small-molecule libraries, as well as nascent strategies for primary drug HTS in eukaryotic cells, including novel methods of target and drug delivery to cells.
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