Optogenetics: Light-driven Actuators and Light-emitting Sensors in Cell Biology
CHAPTER 5: Light-driven Actuators: Spatiotemporal Dynamics of Cellular Signaling Processes
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Published:18 Sep 2018
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Special Collection: 2018 ebook collection
Yoshibumi Ueda, Moritoshi Sato, 2018. "Light-driven Actuators: Spatiotemporal Dynamics of Cellular Signaling Processes", Optogenetics: Light-driven Actuators and Light-emitting Sensors in Cell Biology, Sophie Vriz, Takeaki Ozawa
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Signal transductions play pivotal roles in cellular functional outputs. Previous studies employed systems such as pharmacological inhibition, RNA interference and overexpression of proteins of constitutive active/dominant negative forms. However, these methods fail to manipulate the signal transductions with high spatial and temporal resolution. Recently, the new technology optogenetics emerged, which overcomes the issues that previous methods have. The authors have developed the Magnet system, which allows us to control cell membrane dynamics spatiotemporally with high spatial and temporal resolution. This chapter introduces the authors' work on the Magnet system from development to applications.