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Drug Discovery
The Medicinal Chemist's Guide to Solving ADMET ChallengesCheck Access
Edited by
Patrick Schnider
Patrick Schnider
Bottmingen, Switzerland
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Hardback ISBN:
978-1-78801-227-0
PDF ISBN:
978-1-78801-641-4
EPUB ISBN:
978-1-83916-049-3
Special Collection:
2021 ebook collection
Series:
Drug Discovery Series
No. of Pages:
518
Published online:
20 Aug 2021
Published in print:
27 Aug 2021
Book Chapter
CHAPTER 7: OATPs: The SLCO Family of Organic Anion Transporting Polypeptide Transporters Check Access
By
Pär Matsson
Pär Matsson
Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg
Box 431
SE-405 30 Gothenburg
Sweden
[email protected]
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Published:20 Aug 2021
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Special Collection: 2021 ebook collectionSeries: Drug Discovery Series
Page range:
143 - 159
Citation
M. Karlgren and P. Matsson, in The Medicinal Chemist's Guide to Solving ADMET Challenges, ed. P. Schnider, The Royal Society of Chemistry, 2021, pp. 143-159.
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The organic anion transporting polypeptides (OATP/SLCO) belong to the solute carrier (SLC) transporter superfamily and primarily mediate cellular uptake of anionic substrates in diverse tissues, including the liver, small intestines, kidneys and blood–brain barrier. This chapter summarizes current knowledge about the function of OATP transporters, their preclinical characterization, and the structural determinants of OATP-mediated drug transport and drug–drug interactions with a focus on the liver-specific transporters OATP1B1 and OATP1B3.
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