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Drug Discovery
The Medicinal Chemist's Guide to Solving ADMET ChallengesCheck Access
Edited by
Patrick Schnider
Patrick Schnider
Bottmingen, Switzerland
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Hardback ISBN:
978-1-78801-227-0
PDF ISBN:
978-1-78801-641-4
EPUB ISBN:
978-1-83916-049-3
Special Collection:
2021 ebook collection
Series:
Drug Discovery Series
No. of Pages:
518
Published online:
20 Aug 2021
Published in print:
27 Aug 2021
Book Chapter
CHAPTER 9: Cytochrome P450 Metabolism Check Access
By
Antonia F. Stepan
;
Antonia F. Stepan
Pharma Research and Early Development, F. Hoffmann-La Roche Ltd
Grenzacherstrasse 124
4070 Basel
Switzerland
[email protected]
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R. Scott Obach
R. Scott Obach
Pfizer Worldwide Research and Development
Eastern Point Road
Groton
Connecticut 06340
USA
[email protected]
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Published:20 Aug 2021
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Special Collection: 2021 ebook collectionSeries: Drug Discovery Series
Page range:
173 - 197
Citation
A. F. Stepan and R. S. Obach, in The Medicinal Chemist's Guide to Solving ADMET Challenges, ed. P. Schnider, The Royal Society of Chemistry, 2021, pp. 173-197.
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Cytochrome P450s (CYPs) are a heme containing family of proteins comprising more than 40 human CYP enzymes. CYP oxidation is highly relevant to drug clearance, drug–drug interactions and interpatient variability in pharmacokinetics. Strategies on how to reduce CYP-mediated turnover are highlighted and exemplified.
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