CHAPTER 9: Cytochrome P450 Metabolism
Published:20 Aug 2021
Cytochrome P450s (CYPs) are a heme containing family of proteins comprising more than 40 human CYP enzymes. CYP oxidation is highly relevant to drug clearance, drug–drug interactions and interpatient variability in pharmacokinetics. Strategies on how to reduce CYP-mediated turnover are highlighted and exemplified.