Skip to Main Content
Skip Nav Destination

Aldehyde oxidase (AO) and xanthine oxidase (XO) are metabolizing enzymes contained within the cytosolic compartments of many tissues and species. In recent years, as drug discovery efforts have increasingly targeted new gene families and new chemotypes and applied decades of learning how to reduce P450-mediated metabolism, the role of non-P450 metabolism, such as by AO and XO, has become more prominent. In this chapter, we highlight the main features of this family of metabolising enzymes and support our view that this is an enzyme family of increasing importance in xenobiotic metabolism with several real-life examples.

You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal