CHAPTER 12: Aldehyde and Xanthine Oxidase Metabolism Check Access

Aldehyde oxidase (AO) and xanthine oxidase (XO) are metabolizing enzymes contained within the cytosolic compartments of many tissues and species. In recent years, as drug discovery efforts have increasingly targeted new gene families and new chemotypes and applied decades of learning how to reduce P450-mediated metabolism, the role of non-P450 metabolism, such as by AO and XO, has become more prominent. In this chapter, we highlight the main features of this family of metabolising enzymes and support our view that this is an enzyme family of increasing importance in xenobiotic metabolism with several real-life examples.