Skip Nav Destination
Drug Discovery
The Medicinal Chemist's Guide to Solving ADMET ChallengesCheck Access
Edited by
Patrick Schnider
Patrick Schnider
Bottmingen, Switzerland
Search for other works by this author on:
Hardback ISBN:
978-1-78801-227-0
PDF ISBN:
978-1-78801-641-4
EPUB ISBN:
978-1-83916-049-3
Special Collection:
2021 ebook collection
Series:
Drug Discovery Series
No. of Pages:
518
Published online:
20 Aug 2021
Published in print:
27 Aug 2021
Book Chapter
CHAPTER 14: Sulfation Check Access
By
Yue Pan
Yue Pan
Global Discovery Chemistry, Novartis Institutes for BioMedical Research
22 Windsor St.
Cambridge
Massachusetts 02139
USA
[email protected]
Search for other works by this author on:
-
Published:20 Aug 2021
-
Special Collection: 2021 ebook collectionSeries: Drug Discovery Series
Page range:
303 - 313
Citation
Y. Pan, in The Medicinal Chemist's Guide to Solving ADMET Challenges, ed. P. Schnider, The Royal Society of Chemistry, 2021, pp. 303-313.
Download citation file:
Sulfation catalyzed by sulfotransferase (SULT) is an important part of phase II metabolism. Similar to uridine 5′-diphospho-glucuronosyltransferases (UGTs), SULTs can metabolize certain drug-like molecules, and reactive metabolites may also form as a result. This chapter provides an overview of the SULT family, several medicinal chemistry strategies to reduce or eliminate sulfation and selected examples from the literature.
You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Digital access
$64.60
