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Sulfation catalyzed by sulfotransferase (SULT) is an important part of phase II metabolism. Similar to uridine 5′-diphospho-glucuronosyltransferases (UGTs), SULTs can metabolize certain drug-like molecules, and reactive metabolites may also form as a result. This chapter provides an overview of the SULT family, several medicinal chemistry strategies to reduce or eliminate sulfation and selected examples from the literature.

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