RNA Polymerases as Molecular Motors: On the Road
CHAPTER 10: Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation Mechanisms
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Published:23 Nov 2021
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Special Collection: 2021 ebook collection
Ilona Christy Unarta, Kirill A. Konovalov, Xiaowei Wang, Gianmarco Domenico Suarez, Xuhui Huang, 2021. "Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation Mechanisms", RNA Polymerases as Molecular Motors: On the Road, Robert Landick, Terence Strick, Jue Wang
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Structural features of RNA polymerase (RNAP) are crucial to its catalytic function. RNAPs of bacteria, archaea, and eukaryotes (except mitochondrial RNAP of eukaryotes) are homologous multi-subunit complexes, sharing a high degree of similarity in the core enzyme. The structures of multi-subunit RNAP has been likened to a crab's claw, which is able to clamp and stabilize the transcription bubble. Furthermore, distinct structural features of these polymerases (trigger loop and bridge helix, Figure 10.1A right) play important roles in orchestrating the transcription elongation cycle (TEC). In contrast to multi-subunit RNAPs, the RNAP of T7 bacteriophage (T7 RNAP) is a single subunit...