Nutrition and Cancer Prevention
CHAPTER 12: Nutrition, Epigenetics and Cancer Prevention
Published:27 Nov 2019
Special Collection: 2019 ebook collection
A. de Conti, I. P. Pogribny, S. A. Ross, 2019. "Nutrition, Epigenetics and Cancer Prevention", Nutrition and Cancer Prevention, Thomas Prates Ong, Fernando Salvador Moreno
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The accurate maintenance of the cellular epigenome is one of the mechanisms by which dietary components can prevent or inhibit the development of cancer. Diet can regulate epigenetic mechanisms either directly through the activation or inhibition of chromatin-modifying enzymes or indirectly by providing the necessary metabolites for proper functioning. These concepts can be applied to the cancer preventive strategies in which dietary components alone or in combination with existing chemopreventive agents affect epigenetic mechanisms in favor of carcinogenesis control. Considering the crucial need in developing effective strategies for the prevention of cancer, elucidation of the mechanisms by which nutrients, bioactive food compounds, or dietary patterns modulate epigenetic mechanisms to control carcinogenic processes are of great importance. It is expected that recent advances in modern epigenome-wide technological tools will facilitate the incorporation of dietary components in cancer preventive strategies.