Techno-economic analysis (TEA) plays a critical role in assessing the cost of a technology relative to the current market, in identifying high impact areas for research and development investment, and in informing relevant stakeholders. In this chapter we discuss three main topics: (1) an overview of TEA, its processes, methods, and considerations for developing a good TEA framework; (2) description of the U.S. Department of Energy's H2A Production Model which is used for evaluating their portfolio of hydrogen production research; and (3) a synopsis of currently published H2A case studies illustrating the application of techno-economic analysis to hydrogen production technologies. These technologies include polymer membrane and solid oxide electrolysis, photo-electrochemical, methane steam reforming, coal gasification and use of biomass (via gasification or bio-derived liquids) and solar thermal routes to hydrogen. From the analyses comparisons between various technological approaches can be made in terms of costs, implementation, investment and versatility.