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Drug Discovery
MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets
Edited by
Philip V Peplow;
Philip V Peplow
University of Otago, New Zealand
Search for other works by this author on:
Bridget Martinez;
Bridget Martinez
University of California, Merced, USA
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George A Calin;
George A Calin
MD Anderson Cancer Center, USA
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Aurora Esquela-Kerscher
Aurora Esquela-Kerscher
Eastern Virginia Medical School, USA
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Hardback ISBN:
978-1-78801-394-9
PDF ISBN:
978-1-78801-642-1
EPUB ISBN:
978-1-78801-781-7
Special Collection:
2019 ebook collection
Series:
Drug Discovery
No. of Pages:
480
Published online:
07 May 2019
Published in print:
21 May 2019
About this book
From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors.
With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets, The Royal Society of Chemistry, 2019.
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Digital access
$250.00
Print format
MicroRNAs in Diseases and Disorders
$250.00
Table of contents
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CHAPTER 1: Role of Nutrition, the Epigenome, and MicroRNAs in Cancer Pathogenesisp1-35ByZachary Cadieux;Zachary CadieuxDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr Cancer Research Center, Eastern Virginia Medical SchoolNorfolkVirginiaUSA[email protected]Search for other works by this author on:Holly Lewis;Holly LewisDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr Cancer Research Center, Eastern Virginia Medical SchoolNorfolkVirginiaUSA[email protected]Search for other works by this author on:Aurora Esquela-KerscherAurora Esquela-KerscherDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr Cancer Research Center, Eastern Virginia Medical SchoolNorfolkVirginiaUSA[email protected]Search for other works by this author on:
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CHAPTER 2: Role of MicroRNAs in Metabolic Diseasesp36-75ByRafay M. Syed;Rafay M. SyedRush Medical College600 S. Paulina StChicagoIL 60612USASearch for other works by this author on:Jeffrey A. DeiuliisJeffrey A. DeiuliisCase Western Reserve University2103 Cornell Rd, WRB Rm 4523ClevelandOH 44106USA[email protected][email protected]Search for other works by this author on:
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CHAPTER 3: Circulating MicroRNAs as Biomarkers of Celiac Disease and Other Intestinal Pediatric Diseases: Experimental and Bioinformatics Challenges From Bench to Bedsidep76-104ByCristina Felli;Cristina FelliBambino Gesù Children's Hospital-IRCCS, Research LaboratoriesV.le di San Paolo 1500146RomeItaly[email protected]Search for other works by this author on:Antonella Baldassarre;Antonella BaldassarreBambino Gesù Children's Hospital-IRCCS, Research LaboratoriesV.le di San Paolo 1500146RomeItaly[email protected]Search for other works by this author on:Francesca Ferretti;Francesca FerrettiBambino Gesù Children's Hospital-IRCCS, Hepatology, Gastroenterology and NutritionV.le di San Paolo 1500146RomeItalySearch for other works by this author on:Mariangela Caruso;Mariangela CarusoSapienza University of Rome, Department of PediatricsV.le Regina Elena 32400161RomeItalySearch for other works by this author on:Andrea MasottiAndrea MasottiBambino Gesù Children's Hospital-IRCCS, Research LaboratoriesV.le di San Paolo 1500146RomeItaly[email protected]Search for other works by this author on:
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CHAPTER 4: MicroRNAs and Mycobacterial Infections in Humans and Domestic Animalsp105-132BySarah L. Faherty O'Donnell;Sarah L. Faherty O'DonnellAnimal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Health and Agricultural Sciences, University College DublinDublin D04 V1W8Ireland[email protected]Search for other works by this author on:Carolina N. Correia;Carolina N. CorreiaAnimal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Health and Agricultural Sciences, University College DublinDublin D04 V1W8Ireland[email protected]Search for other works by this author on:David E. MacHughDavid E. MacHughAnimal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Health and Agricultural Sciences, University College DublinDublin D04 V1W8Ireland[email protected]UCD Conway Institute of Biomolecular and Biomedical Research, University College DublinDublin D04 V1W8IrelandSearch for other works by this author on:
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CHAPTER 5: Regulation and Function of MicroRNAs in Kidney Diseasesp133-155ByP. Trionfini;P. TrionfiniIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso24126 BergamoItaly[email protected]Search for other works by this author on:A. BenigniA. BenigniIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso24126 BergamoItaly[email protected]Search for other works by this author on:
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CHAPTER 6: Involvement of MicroRNAs in Autoimmune Diseasesp156-188ByRadhika Raheja;Radhika RahejaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School60 Fenwood Road, Hale Building for Transformative MedicineBostonMA 02115USA[email protected]Search for other works by this author on:Mai Fujiwara;Mai FujiwaraAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School60 Fenwood Road, Hale Building for Transformative MedicineBostonMA 02115USA[email protected]Search for other works by this author on:Lucien P. Garo;Lucien P. GaroAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School60 Fenwood Road, Hale Building for Transformative MedicineBostonMA 02115USA[email protected]Search for other works by this author on:Gopal MurugaiyanGopal MurugaiyanAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School60 Fenwood Road, Hale Building for Transformative MedicineBostonMA 02115USA[email protected]Search for other works by this author on:
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CHAPTER 7: MicroRNAs in Ischemic Stroke, Hemorrhagic Stroke, and Traumatic Brain Injuryp189-223ByBridget MartinezBridget MartinezDepartment of Molecular and Cellular Biology, University of California, MercedMercedCaliforniaUSADepartment of Medicine, St. Georges University School of MedicineGrenadaDepartment of Physics and Engineering, Los Alamos National LaboratoryLos AlamosNew MexicoUSASearch for other works by this author on:
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CHAPTER 8: MicroRNAs as Biomarkers for Neurological Disordersp224-253ByChi-Kwan Leung;Chi-Kwan LeungCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong KongHong KongChinaNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsJinanShandong250001China[email protected]Search for other works by this author on:Gang Lu;Gang LuCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong KongHong KongChinaNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsJinanShandong250001China[email protected]Search for other works by this author on:George Kwok-Chu Wong;George Kwok-Chu WongDivision of Neurosurgery, Department of Surgery, The Chinese University of Hong KongHong KongChinaSearch for other works by this author on:Wai-Yee ChanWai-Yee ChanCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong KongHong KongChinaNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsJinanShandong250001China[email protected]Search for other works by this author on:
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CHAPTER 9: MicroRNAs in Endocrine Disordersp254-274ByLourdes MounienLourdes MounienSearch for other works by this author on:
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CHAPTER 10: MicroRNAs in Skin Development, Function and Disordersp275-292ByDurba Pal;Durba PalCenter for Biomedical Engineering, Indian Institute of Technology—RoparPunjab-140001IndiaSearch for other works by this author on:Chandan K. SenChandan K. SenIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of MedicineIndianapolisIN 46202USA[email protected]Search for other works by this author on:
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CHAPTER 11: MicroRNAs in Haematological Diseasesp293-322ByA. C. P. Mafra;A. C. P. MafraDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center1515 Holcombe Blvd. Unit 1950Zip Code 77030HoustonTexasUSA[email protected]Center for RNA Inference and Non-coding RNAs, The University of Texas MD Anderson Cancer Center1515 Holcombe Blvd. Unit 1950Zip Code 77030HoustonTexasUSABrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM)Rua Giuseppe Maximo Scolfaro 10000Zip Code 13083-970CampinasSao PauloBrazilDepartment of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas – UNICAMPP.O. Box: 6109Zip Code 13083-970CampinasSao PauloBrazilSearch for other works by this author on:G. A. CalinG. A. CalinDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center1515 Holcombe Blvd. Unit 1950Zip Code 77030HoustonTexasUSA[email protected]Center for RNA Inference and Non-coding RNAs, The University of Texas MD Anderson Cancer Center1515 Holcombe Blvd. Unit 1950Zip Code 77030HoustonTexasUSASearch for other works by this author on:
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CHAPTER 12: Discovery and Therapeutic Relevance of Small Molecule Modifiers of MicroRNA Functionp323-363ByNicholas Ankenbruck;Nicholas AnkenbruckDepartment of Chemistry and University of Pittsburgh Cancer InstitutePittsburghPennsylvania 15260USA[email protected]Search for other works by this author on:Yuta Naro;Yuta NaroDepartment of Chemistry and University of Pittsburgh Cancer InstitutePittsburghPennsylvania 15260USA[email protected]Search for other works by this author on:Rohan Kumbhare;Rohan KumbhareDepartment of Chemistry and University of Pittsburgh Cancer InstitutePittsburghPennsylvania 15260USA[email protected]Search for other works by this author on:Alexander DeitersAlexander DeitersDepartment of Chemistry and University of Pittsburgh Cancer InstitutePittsburghPennsylvania 15260USA[email protected]Search for other works by this author on:
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CHAPTER 13: MicroRNA-specific Argonaute 2 Protein Inhibitors and AGO Loading Inhibitorsp364-385ByKatrien Van RoosbroeckKatrien Van RoosbroeckThe University of Texas MD Anderson Cancer Center, Department of Experimental Therapeutics – Unit 19501515 Holcombe BlvdHoustonTX 77030USA[email protected]Search for other works by this author on:
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CHAPTER 14: Strategies for Safe and Targeted Delivery of MicroRNA Therapeuticsp386-415BySunghyun (Sander) Myoung;Sunghyun (Sander) MyoungPurdue University, Department of Biological Sciences1203 West State St.West LafayetteIN47907USA[email protected]Purdue University, Center for Cancer ResearchWest LafayetteIN47907USAPurdue University, Purdue University Interdisciplinary Life Science Program (PULSe)West LafayetteIN47907USASearch for other works by this author on:Andrea L. KasinskiAndrea L. KasinskiPurdue University, Department of Biological Sciences1203 West State St.West LafayetteIN47907USA[email protected]Purdue University, Center for Cancer ResearchWest LafayetteIN47907USASearch for other works by this author on:
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CHAPTER 15: Modification of Drug Response in Cancer by MicroRNAsp416-451ByLaura L. Meijer;Laura L. MeijerDepartment of Surgery, Cancer Center Amsterdam, VU University Medical CenterAmsterdamThe NetherlandsSearch for other works by this author on:Jisce R. Puik;Jisce R. PuikDepartment of Surgery, Cancer Center Amsterdam, VU University Medical CenterAmsterdamThe NetherlandsSearch for other works by this author on:Caterina Vivaldi;Caterina VivaldiDepartment of Medical Oncology, University Hospital of PisaPisaItalySearch for other works by this author on:Mjriam Capula;Mjriam CapulaDepartment of Medical Oncology, Cancer Center Amsterdam, VU University Medical CenterAmsterdamThe Netherlands[email protected]Search for other works by this author on:Enrico Vasile;Enrico VasileDepartment of Medical Oncology, University Hospital of PisaPisaItalySearch for other works by this author on:Geert Kazemier;Geert KazemierDepartment of Surgery, Cancer Center Amsterdam, VU University Medical CenterAmsterdamThe NetherlandsSearch for other works by this author on:Elisa GiovannettiElisa GiovannettiDepartment of Medical Oncology, Cancer Center Amsterdam, VU University Medical CenterAmsterdamThe Netherlands[email protected]Cancer Pharmacology Lab, AIRC-Start-Up Unit, University Hospital of PisaPisaItalySearch for other works by this author on:
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CHAPTER 16: Nanoparticle Delivery of miRNA in Cancerp452-472ByHamada Mokhlis;Hamada MokhlisDepartment of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer CenterHoustonTexas77030USA[email protected]Department of Pharmacology and Toxicology, Faculty of Pharmacy, The University of Al-AzharCairoEgyptSearch for other works by this author on:Bulent OzpolatBulent OzpolatDepartment of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer CenterHoustonTexas77030USA[email protected]Non-Coding RNA Center, The University of Texas M.D. Anderson Cancer CenterHoustonTexas77030USASearch for other works by this author on:
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